Gene Symbol | FAM162A |
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Entrez Gene | 26355 |
Alt Symbol | C3orf28, E2IG5, HGTD-P |
Species | Human |
Gene Type | protein-coding |
Description | family with sequence similarity 162, member A |
Other Description | E2-induced gene 5 protein|HIF-1 alpha-responsive proapoptotic molecule|growth and transformation-dependent protein|protein FAM162A |
Swissprots | Q9UJX8 Q9NRN6 Q96A26 |
Accessions | EAW79486 Q96A26 AF107495 AAG39275 AF191020 AAF09484 AF201944 AAF86880 AF250321 AAG44569 AK026030 AK125835 AK293994 BAG57358 BC010896 AAH10896 BC015060 AAH15060 BI460077 NM_014367 NP_055182 |
Function | Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269|PubMed:15082785}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}. |
HGTD-P CRISPR/Cas9 KO Plasmid (h) - sc-409885 from Santa Cruz Biotechnology
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HGTD-P HDR Plasmid (h) - sc-409885-HDR from Santa Cruz Biotechnology
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HGTD-P Double Nickase Plasmid (h) - sc-409885-NIC from Santa Cruz Biotechnology
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HGTD-P Double Nickase Plasmid (h2) - sc-409885-NIC-2 from Santa Cruz Biotechnology
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HGTD-P CRISPR Activation Plasmid (h) - sc-409885-ACT from Santa Cruz Biotechnology
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HGTD-P CRISPR Activation Plasmid (h2) - sc-409885-ACT-2 from Santa Cruz Biotechnology
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HGTD-P Lentiviral Activation Particles (h) - sc-409885-LAC from Santa Cruz Biotechnology
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HGTD-P Lentiviral Activation Particles (h2) - sc-409885-LAC-2 from Santa Cruz Biotechnology
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HGTD-P siRNA (h) - sc-78235 from Santa Cruz Biotechnology
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HGTD-P shRNA Plasmid (h) - sc-78235-SH from Santa Cruz Biotechnology
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HGTD-P shRNA (h) Lentiviral Particles - sc-78235-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8213 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8213 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01882 from Sigma-Aldrich
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FAM162A siRNA (Human) - CRH8822 from Cohesion Biosciences
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FAM162A - MBS8209562 from MyBioSource
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shRNA set against Human FAM162A (NM_014367.3) - SHH289945 from Creative biogene
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FAM162A shRNA Plasmid (Human) - CHH8822 from Cohesion Biosciences
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FAM162A miRNA 3'UTR clone - MiUTR1H-01385 from Creative biogene
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