| Gene Symbol |
HJURP
|
| Entrez Gene |
55355
|
| Alt Symbol |
FAKTS, URLC9, hFLEG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Holliday junction recognition protein
|
| Other Description |
14-3-3-associated AKT substrate|fetal liver expressing gene 1|fetal liver-expressing gene 1 protein|up-regulated in lung cancer 9
|
| Swissprots |
A8IRH5 Q9NSL8 Q9BUT2 B4DWR0 Q8NCD3 B4DZV4
|
| Accessions |
EAW71064 EAW71065 Q8NCD3 AB101211 BAF82039 AB162218 BAD36741 AK074809 BAC11221 AK301643 BAG63122 AK303109 BAG64216 AL162048 CAB82391 BC001940 AAH01940 BE535238 BM148072 BM475244 BM838206 BQ225710 CA441903 CF619091 DB022872 DB319863 DN998761 XM_011511437 XP_011509739 NM_001282962 NP_001269891 NM_001282963 NP_001269892 NM_018410 NP_060880
|
| Function |
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.
|
| Subcellular Location |
Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
|
| Tissue Specificity |
According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. {ECO:0000269|PubMed:17256767, ECO:0000269|PubMed:17823411}.
|