| Gene Symbol |
LPIN2
|
| Entrez Gene |
9663
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipin 2
|
| Other Description |
lipin-2|phosphatidate phosphatase LPIN2
|
| Swissprots |
D3DUH3 A7MD25 Q92539
|
| Accessions |
EAX01686 EAX01687 Q92539 BC152448 AAI52449 BC160018 AAI60018 BQ014306 D87436 BAA13380 XM_005258177 XP_005258234 XM_005258178 XP_005258235 XM_005258179 XP_005258236 XR_935074 NM_014646 NP_055461
|
| Function |
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. {ECO:0000269|PubMed:15994876, ECO:0000269|PubMed:17158099}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|