Gene Symbol | LPIN2 |
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Entrez Gene | 9663 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | lipin 2 |
Other Description | lipin-2|phosphatidate phosphatase LPIN2 |
Swissprots | D3DUH3 A7MD25 Q92539 |
Accessions | EAX01686 EAX01687 Q92539 BC152448 AAI52449 BC160018 AAI60018 BQ014306 D87436 BAA13380 XM_005258177 XP_005258234 XM_005258178 XP_005258235 XM_005258179 XP_005258236 XR_935074 NM_014646 NP_055461 |
Function | Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate. {ECO:0000250}. |
Tissue Specificity | Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. {ECO:0000269|PubMed:15994876, ECO:0000269|PubMed:17158099}. |
Top Pathways | Glycerolipid metabolism, Glycerophospholipid metabolism |
Lipin 2 peptide (882-896) - ab45703 from Abcam
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LPIN2 / Lipin 2 Antibody Blocking Peptide - LS-E25837 from LifeSpan Bioscience
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LPIN2 / Lipin 2 Antibody Blocking Peptide - LS-E22497 from LifeSpan Bioscience
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LPIN2 / Lipin 2 Antibody Blocking Peptide - LS-E9655 from LifeSpan Bioscience
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LPIN2-Antibody-Center-Blocking-Peptide - BP8583c from Abgent, a WuXi AppTec company
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Lipin 2 blocking peptide - GTX89604-PEP from GeneTex
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Lipin 2 Blocking Peptide - 33R-10945 from Fitzgerald
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LPIN2 Blocking Peptide - 33R-2554 from Fitzgerald
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Lipin 2 Peptide - AC21-0669-P from Abcore
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Lipin 2 Peptide - 45-836P from ProSci
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Recombinant Human Phosphatidate phosphatase LPIN2(LPIN2) ,partial - CSB-YP838780HU CSB-EP838780HU CSB-BP838780HU CSB-MP838780HU from Cusabio
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Lipin 2 Blocking Peptide - 3832BP-50 from Biovision
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Lipin-2 - TP324070 from Acris Antibodies
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Phosphatidate phosphatase LPIN2 (LPIN2), partial, Recombinant Protein - MBS1419788 from MyBioSource
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Lipin 2, Peptide - MBS426576 from MyBioSource
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Lipin 2 Protein - NBP1-87853PEP from Novus Biologicals
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Lipin 2 Recombinant Protein Antigen - NBP2-33931PEP from Novus Biologicals
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LPIN2 Peptide, Human - M34GP08820H from Creative Peptides
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LPIN2 Immunizing peptide - orb17216 from Biorbyt
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