| Gene Symbol |
KHDRBS1
|
| Entrez Gene |
10657
|
| Alt Symbol |
Sam68, p62, p68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KH domain containing, RNA binding, signal transduction associated 1
|
| Other Description |
GAP-associated tyrosine phosphoprotein p62 (Sam68)|KH domain-containing, RNA-binding, signal transduction-associated protein 1|p21 Ras GTPase-activating protein-associated p62|src-associated in mitosis 68 kDa protein
|
| Swissprots |
D3DPP3 Q8NB97 Q07666 Q99760 Q6PJX7
|
| Accessions |
EAX07574 EAX07575 EAX07576 EAX07577 Q07666 AK091346 BAC03643 AK293369 BAG56883 AK303218 BAG64305 AK312916 BAG35762 BC000717 AAH00717 BC010132 AAH10132 BC019109 AAH19109 CA442272 CN345570 DB365017 DC351638 DQ895323 ABM86249 M88108 AAA59990 U78971 AAB47504 NM_001271878 NP_001258807 NM_006559 NP_006550 NR_073498 NR_073499
|
| Function |
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). {ECO:0000269|PubMed:22253824}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:1374686}. Membrane {ECO:0000269|PubMed:1374686}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. {ECO:0000269|PubMed:9013542}.
|