KHDRBS1

Gene Symbol	KHDRBS1
Entrez Gene	10657
Alt Symbol	Sam68, p62, p68
Species	Human
Gene Type	protein-coding
Description	KH domain containing, RNA binding, signal transduction associated 1
Other Description	GAP-associated tyrosine phosphoprotein p62 (Sam68)|KH domain-containing, RNA-binding, signal transduction-associated protein 1|p21 Ras GTPase-activating protein-associated p62|src-associated in mitosis 68 kDa protein
Swissprots	D3DPP3 Q8NB97 Q07666 Q99760 Q6PJX7
Accessions	EAX07574 EAX07575 EAX07576 EAX07577 Q07666 AK091346 BAC03643 AK293369 BAG56883 AK303218 BAG64305 AK312916 BAG35762 BC000717 AAH00717 BC010132 AAH10132 BC019109 AAH19109 CA442272 CN345570 DB365017 DC351638 DQ895323 ABM86249 M88108 AAA59990 U78971 AAB47504 NM_001271878 NP_001258807 NM_006559 NP_006550 NR_073498 NR_073499
Function	Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). {ECO:0000269|PubMed:22253824}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:1374686}. Membrane {ECO:0000269|PubMed:1374686}.
Tissue Specificity	Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. {ECO:0000269|PubMed:9013542}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SAM68 full length protein - ab132147 from Abcam Category Protein Source Wheat germ Species Human

Human SAM68 peptide - ab27829 from Abcam Category Peptide

Human SAM68 protein fragment - ab153110 from Abcam Category Protein Source Wheat germ Species Human

KHDRBS1 / SAM68 Antibody Blocking Peptide - LS-E14891 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KHDRBS1 / SAM68 Antibody Blocking Peptide - LS-E14892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KHDRBS1 / SAM68 Antibody Blocking Peptide - LS-E6569 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KHDRBS1 / SAM68 Antibody Blocking Peptide - LS-E13319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SAM68 Protein - H00010657-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SAM68 Protein - H00010657-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KHDRBS1 Blocking Peptide - 33R-7267 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KHDRBS1 Blocking Peptide - 33R-6342 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KHDRBS1 Blocking Peptide - 33R-5263 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SAM68 / KHDRBS1 - H00010657-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SAM68 / KHDRBS1 - H00010657-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SAM68 / KHDRBS1 - H00010657-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SAM68 / KHDRBS1 - H00010657-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Sam68 fusion protein - ag0235 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human KHDRBS1, GST-tagged - KHDRBS1-2876H from Creative Biomart Category Protein Source wheat germ Species Human

Recombinant Human KH domain containing, RNA binding, signal transduction associated 1, GST-tag - KHDRBS1-2877H from Creative Biomart Category Protein Source wheat germ Species Human

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) - RPL650Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) - RPL650Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Sam 68 (Y145) Peptide - BS2952P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) - RPL616Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) - RPL650Hu01 from Cloud-clone Category Protein Source E.coli Species Human

p62 Protein (OPPB00006) - OPPB00006 from Aviva Systems Biology Category Protein Prices $485.00 Sizes 25 µg

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