KHDRBS1
| Gene Symbol | KHDRBS1 |
|---|---|
| Entrez Gene | 10657 |
| Alt Symbol | Sam68, p62, p68 |
| Species | Human |
| Gene Type | protein-coding |
| Description | KH domain containing, RNA binding, signal transduction associated 1 |
| Other Description | GAP-associated tyrosine phosphoprotein p62 (Sam68)|KH domain-containing, RNA-binding, signal transduction-associated protein 1|p21 Ras GTPase-activating protein-associated p62|src-associated in mitosis 68 kDa protein |
| Swissprots | D3DPP3 Q8NB97 Q07666 Q99760 Q6PJX7 |
| Accessions | EAX07574 EAX07575 EAX07576 EAX07577 Q07666 AK091346 BAC03643 AK293369 BAG56883 AK303218 BAG64305 AK312916 BAG35762 BC000717 AAH00717 BC010132 AAH10132 BC019109 AAH19109 CA442272 CN345570 DB365017 DC351638 DQ895323 ABM86249 M88108 AAA59990 U78971 AAB47504 NM_001271878 NP_001258807 NM_006559 NP_006550 NR_073498 NR_073499 |
| Function | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). {ECO:0000269|PubMed:22253824}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:1374686}. Membrane {ECO:0000269|PubMed:1374686}. |
| Tissue Specificity | Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. {ECO:0000269|PubMed:9013542}. |
Sam 68 CRISPR/Cas9 KO Plasmid (h) - sc-401378 from Santa Cruz Biotechnology
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Sam 68 HDR Plasmid (h) - sc-401378-HDR from Santa Cruz Biotechnology
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Sam 68 Double Nickase Plasmid (h) - sc-401378-NIC from Santa Cruz Biotechnology
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Sam 68 Double Nickase Plasmid (h2) - sc-401378-NIC-2 from Santa Cruz Biotechnology
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Sam 68 CRISPR Activation Plasmid (h) - sc-401378-ACT from Santa Cruz Biotechnology
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Sam 68 CRISPR Activation Plasmid (h2) - sc-401378-ACT-2 from Santa Cruz Biotechnology
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Sam 68 Lentiviral Activation Particles (h) - sc-401378-LAC from Santa Cruz Biotechnology
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Sam 68 Lentiviral Activation Particles (h2) - sc-401378-LAC-2 from Santa Cruz Biotechnology
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Sam 68 siRNA (h) - sc-29476 from Santa Cruz Biotechnology
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Sam 68 shRNA Plasmid (h) - sc-29476-SH from Santa Cruz Biotechnology
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Sam 68 shRNA (h) Lentiviral Particles - sc-29476-V from Santa Cruz Biotechnology
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SAM68 RNAi - H00010657-R01 from Novus Biologicals
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MISSION® esiRNA - EHU140681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11047 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11047 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09033 from Sigma-Aldrich
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KHDRBS1 siRNA (Human) - CRH7265 from Cohesion Biosciences
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shRNA set against Human KHDRBS1 (NM_006559.1) - SHH324387 from Creative biogene
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shRNA set against Human KHDRBS1(NM_006559.1) - SHL194048 from Creative biogene
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Human KHDRBS1 siRNA - orb267767 from Biorbyt
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KHDRBS1 shRNA Plasmid (Human) - CHH7265 from Cohesion Biosciences
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KHDRBS1 miRNA 3'UTR clone - MiUTR1H-05192 from Creative biogene
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