| Gene Symbol | ACOT2 |
|---|---|
| Entrez Gene | 10965 |
| Alt Symbol | CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 2 |
| Other Description | acyl-coenzyme A thioester hydrolase 2a|acyl-coenzyme A thioesterase 2, mitochondrial|long-chain acyl-CoA thioesterase 2|mitochondrial acyl-CoA thioesterase 1|peroxisomal long-chain acyl-coA thioesterase 2 |
| Swissprots | Q3I5F8 P49753 Q9NUX4 Q53EK4 |
| Accessions | P49753 AI537078 AK001939 BAA91989 AK093131 BAG52662 AK223635 BAD97355 AY005822 AAF97985 BC004436 AAH04436 BC006335 AAH06335 BC006500 AAH06500 DQ082755 AAZ31237 DQ893488 ABM84414 DQ896406 ABM87405 L40401 AAC42007 XM_006720007 XP_006720070 NM_006821 NP_006812 NR_046028 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269|PubMed:10944470}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16940157}. |
| Tissue Specificity | Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269|PubMed:16940157}. |
| Top Pathways | Ovarian steroidogenesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids |