| Gene Symbol |
ACOT2
|
| Entrez Gene |
10965
|
| Alt Symbol |
CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA thioesterase 2
|
| Other Description |
acyl-coenzyme A thioester hydrolase 2a|acyl-coenzyme A thioesterase 2, mitochondrial|long-chain acyl-CoA thioesterase 2|mitochondrial acyl-CoA thioesterase 1|peroxisomal long-chain acyl-coA thioesterase 2
|
| Swissprots |
Q3I5F8 P49753 Q9NUX4 Q53EK4
|
| Accessions |
P49753 AI537078 AK001939 BAA91989 AK093131 BAG52662 AK223635 BAD97355 AY005822 AAF97985 BC004436 AAH04436 BC006335 AAH06335 BC006500 AAH06500 DQ082755 AAZ31237 DQ893488 ABM84414 DQ896406 ABM87405 L40401 AAC42007 XM_006720007 XP_006720070 NM_006821 NP_006812 NR_046028
|
| Function |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269|PubMed:10944470}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:16940157}.
|
| Tissue Specificity |
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269|PubMed:16940157}.
|
| Top Pathways |
Ovarian steroidogenesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids
|