Gene Symbol | ACOT2 |
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Entrez Gene | 10965 |
Alt Symbol | CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA thioesterase 2 |
Other Description | acyl-coenzyme A thioester hydrolase 2a|acyl-coenzyme A thioesterase 2, mitochondrial|long-chain acyl-CoA thioesterase 2|mitochondrial acyl-CoA thioesterase 1|peroxisomal long-chain acyl-coA thioesterase 2 |
Swissprots | Q3I5F8 P49753 Q9NUX4 Q53EK4 |
Accessions | P49753 AI537078 AK001939 BAA91989 AK093131 BAG52662 AK223635 BAD97355 AY005822 AAF97985 BC004436 AAH04436 BC006335 AAH06335 BC006500 AAH06500 DQ082755 AAZ31237 DQ893488 ABM84414 DQ896406 ABM87405 L40401 AAC42007 XM_006720007 XP_006720070 NM_006821 NP_006812 NR_046028 |
Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269|PubMed:10944470}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16940157}. |
Tissue Specificity | Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269|PubMed:16940157}. |
Top Pathways | Ovarian steroidogenesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids |
ACOT2 CRISPR/Cas9 KO Plasmid (h) - sc-411542 from Santa Cruz Biotechnology
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ACOT2 HDR Plasmid (h) - sc-411542-HDR from Santa Cruz Biotechnology
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ACOT2 Double Nickase Plasmid (h) - sc-411542-NIC from Santa Cruz Biotechnology
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ACOT2 Double Nickase Plasmid (h2) - sc-411542-NIC-2 from Santa Cruz Biotechnology
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ACOT2 CRISPR Activation Plasmid (h) - sc-411542-ACT from Santa Cruz Biotechnology
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ACOT2 CRISPR Activation Plasmid (h2) - sc-411542-ACT-2 from Santa Cruz Biotechnology
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ACOT2 Lentiviral Activation Particles (h) - sc-411542-LAC from Santa Cruz Biotechnology
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ACOT2 Lentiviral Activation Particles (h2) - sc-411542-LAC-2 from Santa Cruz Biotechnology
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ACOT2 siRNA (h) - sc-72435 from Santa Cruz Biotechnology
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ACOT2 shRNA Plasmid (h) - sc-72435-SH from Santa Cruz Biotechnology
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ACOT2 shRNA (h) Lentiviral Particles - sc-72435-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU104751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2728 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2728 from Sigma-Aldrich
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ACOT2 siRNA (Human) - CRH7486 from Cohesion Biosciences
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ACOT2 - MBS8222240 from MyBioSource
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shRNA set against Human ACOT2 (NM_006821.5) - SHH230414 from Creative biogene
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ACOT2 shRNA Plasmid (Human) - CHH7486 from Cohesion Biosciences
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ACOT2 miRNA 3'UTR clone - MiUTR3H-10930 from Creative biogene
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