| Gene Symbol |
FBXO22
|
| Entrez Gene |
26263
|
| Alt Symbol |
FBX22, FISTC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 22
|
| Other Description |
F-box only protein 22|F-box protein FBX22p44|FIST domain containing 1
|
| Swissprots |
Q8IXW3 Q9H824 Q8NEZ5 Q6PIL5 Q9UKC0 Q0D2P8
|
| Accessions |
AAF04523 EAW99229 EAW99230 EAW99231 EAW99232 Q8NEZ5 AK024048 BAB14798 AK026282 AK223500 BAD97220 AK294311 BAG57588 AK307084 AL705285 AL705308 AW292124 AY005144 AAF89095 BC020204 AAH20204 BC032540 AAH32540 BC039024 AAH39024 BC041691 AAH41691 BE738571 BG328756 HQ448526 ADQ33005 XM_011521447 XP_011519749 NM_012170 NP_036302 NM_147188 NP_671717 NR_037623
|
| Function |
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269|PubMed:22972877}.
|
| Subcellular Location |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in liver, also enriched in cardiac muscle. {ECO:0000269|PubMed:22972877}.
|