FBXO22

Gene Symbol	FBXO22
Entrez Gene	26263
Alt Symbol	FBX22, FISTC1
Species	Human
Gene Type	protein-coding
Description	F-box protein 22
Other Description	F-box only protein 22|F-box protein FBX22p44|FIST domain containing 1
Swissprots	Q8IXW3 Q9H824 Q8NEZ5 Q6PIL5 Q9UKC0 Q0D2P8
Accessions	AAF04523 EAW99229 EAW99230 EAW99231 EAW99232 Q8NEZ5 AK024048 BAB14798 AK026282 AK223500 BAD97220 AK294311 BAG57588 AK307084 AL705285 AL705308 AW292124 AY005144 AAF89095 BC020204 AAH20204 BC032540 AAH32540 BC039024 AAH39024 BC041691 AAH41691 BE738571 BG328756 HQ448526 ADQ33005 XM_011521447 XP_011519749 NM_012170 NP_036302 NM_147188 NP_671717 NR_037623
Function	Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269|PubMed:22972877}.
Subcellular Location	Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Tissue Specificity	Predominantly expressed in liver, also enriched in cardiac muscle. {ECO:0000269|PubMed:22972877}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO22 CRISPR/Cas9 KO Plasmid (h) - sc-406260 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 HDR Plasmid (h) - sc-406260-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 Double Nickase Plasmid (h) - sc-406260-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 Double Nickase Plasmid (h2) - sc-406260-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 CRISPR Activation Plasmid (h) - sc-406260-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 CRISPR Activation Plasmid (h2) - sc-406260-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 Lentiviral Activation Particles (h) - sc-406260-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 Lentiviral Activation Particles (h2) - sc-406260-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO22 siRNA (h) - sc-90142 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO22 shRNA Plasmid (h) - sc-90142-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO22 shRNA (h) Lentiviral Particles - sc-90142-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO22 RNAi - H00026263-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU143331 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8540 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8540 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09519 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09519

FBXO22 siRNA (Human) - CRH8788 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBXO22 RNAi - H00026263-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FBXO22 - MBS8224037 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FBXO22 (NM_012170.3) - SHH293121 from Creative biogene Category siRNA Species Reactivities Human

Human FBXO22 siRNA - orb269290 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBXO22 shRNA Plasmid (Human) - CHH8788 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FBXO22 miRNA 3'UTR clone - MiUTR3H-10402 from Creative biogene Species Reactivities Human

FBXO22 miRNA 3'UTR clone - MiUTR3H-10403 from Creative biogene Species Reactivities Human

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