| Gene Symbol |
NEK1
|
| Entrez Gene |
4750
|
| Alt Symbol |
NY-REN-55, SRPS2, SRPS2A, SRTD6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 1
|
| Other Description |
NIMA (never in mitosis gene a)-related kinase 1|never in mitosis A-related kinase 1|nimA-related protein kinase 1|protein-serine/threonine kinase|renal carcinoma antigen NY-REN-55|serine/threonine-protein kinase Nek1
|
| Swissprots |
Q5H9T1 Q9Y594 Q05DG5 G5E9Z3 Q96PY6 Q96SS2 Q9H6P7 Q6PIB8 Q14CB7
|
| Accessions |
EAX04787 EAX04788 EAX04789 EAX04790 EAX04791 Q96PY6 AB067488 BAB67794 AF155113 AAD42879 AI984346 AK025658 BAB15207 AK027580 BAB55209 AL050385 CAI46225 BC015147 AAH15147 BC037790 AAH37790 BC068201 BC114491 AAI14492 CD358162 CR933642 CAI45943 CR936672 DA697159 Z25431 CAA80918 XM_006714228 XP_006714291 XM_011532003 XP_011530305 XM_011532004 XP_011530306 XM_011532005 XP_011530307 NM_001199397 NP_001186326 NM_001199398 NP_001186327 NM_001199399 NP_001186328 NM_001199400 NP_001186329 NM_012224 NP_036356
|
| Function |
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. {ECO:0000250, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:21211617}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
High fetal expression in the brain and kidney. {ECO:0000269|PubMed:21211617}.
|