NEK1

Gene Symbol NEK1
Entrez Gene 4750
Alt Symbol NY-REN-55, SRPS2, SRPS2A, SRTD6
Species Human
Gene Type protein-coding
Description NIMA-related kinase 1
Other Description NIMA (never in mitosis gene a)-related kinase 1|never in mitosis A-related kinase 1|nimA-related protein kinase 1|protein-serine/threonine kinase|renal carcinoma antigen NY-REN-55|serine/threonine-protein kinase Nek1
Swissprots Q5H9T1 Q9Y594 Q05DG5 G5E9Z3 Q96PY6 Q96SS2 Q9H6P7 Q6PIB8 Q14CB7
Accessions EAX04787 EAX04788 EAX04789 EAX04790 EAX04791 Q96PY6 AB067488 BAB67794 AF155113 AAD42879 AI984346 AK025658 BAB15207 AK027580 BAB55209 AL050385 CAI46225 BC015147 AAH15147 BC037790 AAH37790 BC068201 BC114491 AAI14492 CD358162 CR933642 CAI45943 CR936672 DA697159 Z25431 CAA80918 XM_006714228 XP_006714291 XM_011532003 XP_011530305 XM_011532004 XP_011530306 XM_011532005 XP_011530307 NM_001199397 NP_001186326 NM_001199398 NP_001186327 NM_001199399 NP_001186328 NM_001199400 NP_001186329 NM_012224 NP_036356
Function Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. {ECO:0000250, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.
Subcellular Location Nucleus {ECO:0000305|PubMed:21211617}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity). {ECO:0000250}.
Tissue Specificity High fetal expression in the brain and kidney. {ECO:0000269|PubMed:21211617}.

Nek1 CRISPR/Cas9 KO Plasmid (h) - sc-403501 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 HDR Plasmid (h) - sc-403501-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 Double Nickase Plasmid (h) - sc-403501-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 Double Nickase Plasmid (h2) - sc-403501-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 CRISPR Activation Plasmid (h) - sc-403501-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 CRISPR Activation Plasmid (h2) - sc-403501-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 Lentiviral Activation Particles (h) - sc-403501-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 Lentiviral Activation Particles (h2) - sc-403501-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek1 siRNA (h) - sc-106907 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nek1 shRNA Plasmid (h) - sc-106907-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nek1 shRNA (h) Lentiviral Particles - sc-106907-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEK1 RNAi - H00004750-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® siRNA - SIHK1385 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1384 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1386 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1962 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1962 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NEK1 siRNA (Human) - CRH3153 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NEK1 (NM_012224.2) - SHH351196 from Creative biogene

Category siRNA
Species Reactivities Human

Human NEK1 siRNA - orb263655 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NEK1 shRNA Plasmid (Human) - CHH3153 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NEK1 miRNA 3'UTR clone - MiUTR3H-06933 from Creative biogene

Species Reactivities Human
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