| Gene Symbol |
DLL1
|
| Entrez Gene |
28514
|
| Alt Symbol |
DELTA1, DL1, Delta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
delta-like 1 (Drosophila)
|
| Other Description |
H-Delta-1|delta-like protein 1|drosophila Delta homolog 1
|
| Swissprots |
Q9UJV2 B2RAK7 O00548 Q9NU41 B5M0B3
|
| Accessions |
AAG09716 EAW47425 O00548 AF196571 AAF05834 AK311474 AK314234 BAG36904 AY358892 AAQ89251 BC028096 BC152803 AAI52804 DA243552 DR000029 EU927387 ACH57449 XM_005266934 XP_005266991 XM_006725014 XP_006725077 XM_011535758 XP_011534060 XM_011546480 XP_011544782 NM_005618 NP_005609
|
| Function |
Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. {ECO:0000269|PubMed:11581320}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
|
| Top Pathways |
Notch signaling pathway
|
![Western Blot: DLL1 Overexpression Lysate (Adult Normal) [NBL1-09914] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DLL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26234_DLL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09914-img0002.jpg)