Gene Symbol | DLL1 |
---|---|
Entrez Gene | 28514 |
Alt Symbol | DELTA1, DL1, Delta |
Species | Human |
Gene Type | protein-coding |
Description | delta-like 1 (Drosophila) |
Other Description | H-Delta-1|delta-like protein 1|drosophila Delta homolog 1 |
Swissprots | Q9UJV2 B2RAK7 O00548 Q9NU41 B5M0B3 |
Accessions | AAG09716 EAW47425 O00548 AF196571 AAF05834 AK311474 AK314234 BAG36904 AY358892 AAQ89251 BC028096 BC152803 AAI52804 DA243552 DR000029 EU927387 ACH57449 XM_005266934 XP_005266991 XM_006725014 XP_006725077 XM_011535758 XP_011534060 XM_011546480 XP_011544782 NM_005618 NP_005609 |
Function | Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. {ECO:0000269|PubMed:11581320}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
Top Pathways | Notch signaling pathway |