DLL1

Gene Symbol DLL1
Entrez Gene 28514
Alt Symbol DELTA1, DL1, Delta
Species Human
Gene Type protein-coding
Description delta-like 1 (Drosophila)
Other Description H-Delta-1|delta-like protein 1|drosophila Delta homolog 1
Swissprots Q9UJV2 B2RAK7 O00548 Q9NU41 B5M0B3
Accessions AAG09716 EAW47425 O00548 AF196571 AAF05834 AK311474 AK314234 BAG36904 AY358892 AAQ89251 BC028096 BC152803 AAI52804 DA243552 DR000029 EU927387 ACH57449 XM_005266934 XP_005266991 XM_006725014 XP_006725077 XM_011535758 XP_011534060 XM_011546480 XP_011544782 NM_005618 NP_005609
Function Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. {ECO:0000269|PubMed:11581320}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
Top Pathways Notch signaling pathway

Human DLL1 peptide - ab88150 from Abcam

Category Peptide

Human DLL1 protein fragment - ab162166 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162166 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human DLL1 protein fragment - ab108952 from Abcam

Category Protein
Source HEK 293 cells
Species Human
Induction of Hes1 with the treatment of ab108952. A mouse preadpipocyte cell line, 3T3L1, was stimulated with 5ug/ml of ab108952 as in indicated time points and each cell lysate was prepared and subjected to western blot by using anti-Mouse Hes1 or GAPDH.

Human DLL1 protein fragment - ab108576 from Abcam

Category Protein
Source HEK 293 cells
Species Human
Adipogenesis inhibition of MSCs. MSCs (Mesenchymal stem cells) were maintained in DMEM, supplemented with 10% fetal bovine serum, penicilin-streptomycin and glutamine. For differentiation of MSCs, MSCs were cultured in adipogenic medium which was growth medium supplemented with 1µM Dexamethasone, 0.5mM IBMX, 10µg/m lnsulin, 100µM Indomethacin (day 1). Medium was changed every 3 days. Staining with Oil Red O was typically performed on day 30. For negative controls, TNF-alpha (20ng/ml) was added. To immobilize Notch ligands on the plastic surface of the culture plates, plates were first incubated with a solution of anti-FLAG® antibody (10µg/ml) in PBS for 30 mins at 37°C. Coated plates were blocked with growth medium for at least 30mins, incubated with solution of ab108576 (5µg/ml) or mCD137L-FLAG® (5µg/ml) in growth medium for 2 hours at 37°C. Plates were then used to differentiate MSCs.

Mouse DLL1 protein fragment - ab108549 from Abcam

Category Protein
Source HEK 293 cells
Species Mouse
Adipogenesis inhibition. Macroscopic pictures.

DLL1 Antibody Blocking Peptide - LS-E16972 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

DLL1 Antibody Blocking Peptide - LS-E27033 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

DLL1 Partial Recombinant Protein - H00028514-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

sDLL1 Recombinant Protein (Active) - GTX48018-PRO from GeneTex

Category Protein
Prices $299.00
Sizes 25 μg
Source Human
Species Human

DLL1 blocking peptide - GTX88445-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Rat

SCNN1D blocking peptide - GTX88342-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human

Recombinant Human DLL1, CF - 1818-DL-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

DLL1 Blocking Peptide - 33R-3580 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

YY1 protein (His tag) - 80R-3990 from Fitzgerald

Category Protein
Prices $375.00
Sizes 100 µg
Source E.coli

CaMK2 alpha/delta (pT286) Blocking Peptide - abx161313 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Chicken, Monkey, Pig, Rabbit

DLL1 Peptide - AC21-1856-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

Delta-like protein 1 - AR20020PU-N from Acris Antibodies

Category Protein
Prices $235.00
Sizes 25 µg
Source HEK293 cells
Species Human

Delta-like protein 1 - AR20020PU-S from Acris Antibodies

Category Protein
Prices $135.00
Sizes 5 µg
Source HEK293 cells
Species Human

Delta-like protein 1 - H00008788-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Delta-like protein 1 - H00008788-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Delta-like protein 1 - H00028514-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Delta-like protein 1 - H00028514-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Delta-like protein 1 - P5969 from Acris Antibodies

Category Protein
Prices $580.00
Sizes 25 µg
Species Human

sDLL-1, Human, Recombinant - 28-10113 from ARP American Research Products

Category Protein
Prices $99.00, $102.00, $199.00
Sizes 5 µg, 1 mg, 25 µg
Source HEK293 cells
Species Human

DLL1 Peptide - 46-984P from ProSci

Category Peptide
Species Mouse, Rat
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