Gene Symbol | DLL1 |
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Entrez Gene | 28514 |
Alt Symbol | DELTA1, DL1, Delta |
Species | Human |
Gene Type | protein-coding |
Description | delta-like 1 (Drosophila) |
Other Description | H-Delta-1|delta-like protein 1|drosophila Delta homolog 1 |
Swissprots | Q9UJV2 B2RAK7 O00548 Q9NU41 B5M0B3 |
Accessions | AAG09716 EAW47425 O00548 AF196571 AAF05834 AK311474 AK314234 BAG36904 AY358892 AAQ89251 BC028096 BC152803 AAI52804 DA243552 DR000029 EU927387 ACH57449 XM_005266934 XP_005266991 XM_006725014 XP_006725077 XM_011535758 XP_011534060 XM_011546480 XP_011544782 NM_005618 NP_005609 |
Function | Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. {ECO:0000269|PubMed:11581320}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
Top Pathways | Notch signaling pathway |
Delta CRISPR/Cas9 KO Plasmid (h) - sc-400790 from Santa Cruz Biotechnology
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Delta HDR Plasmid (h) - sc-400790-HDR from Santa Cruz Biotechnology
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Delta Double Nickase Plasmid (h) - sc-400790-NIC from Santa Cruz Biotechnology
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Delta Double Nickase Plasmid (h2) - sc-400790-NIC-2 from Santa Cruz Biotechnology
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Delta CRISPR Activation Plasmid (h) - sc-400790-ACT from Santa Cruz Biotechnology
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Delta CRISPR Activation Plasmid (h2) - sc-400790-ACT-2 from Santa Cruz Biotechnology
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Delta Lentiviral Activation Particles (h) - sc-400790-LAC from Santa Cruz Biotechnology
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Delta Lentiviral Activation Particles (h2) - sc-400790-LAC-2 from Santa Cruz Biotechnology
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Delta siRNA (h) - sc-37200 from Santa Cruz Biotechnology
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Delta shRNA Plasmid (h) - sc-37200-SH from Santa Cruz Biotechnology
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Delta shRNA (h) Lentiviral Particles - sc-37200-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7296 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7296 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05657 from Sigma-Aldrich
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DLL1 siRNA (Human) - CRH9120 from Cohesion Biosciences
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DLL1 RNAi - H00028514-R01 from Novus Biologicals
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DLL1 - MBS8236666 from MyBioSource
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Delta CRISPR/Cas9 KO Plasmid (h2) - sc-400790-KO-2 from Santa Cruz Biotechnology
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Delta HDR Plasmid (h2) - sc-400790-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DLL1(NM_005618.3) - SHH007139 from Creative biogene
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Human DLL1 siRNA - orb269622 from Biorbyt
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DLL1 shRNA Plasmid (Human) - CHH9120 from Cohesion Biosciences
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DLL1 miRNA 3'UTR clone - MiUTR1H-02871 from Creative biogene
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