| Gene Symbol |
TSLP
|
| Entrez Gene |
85480
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thymic stromal lymphopoietin
|
| Other Description |
-
|
| Swissprots |
Q8IW99 G3XAM8 Q96AU7 Q969D9
|
| Accessions |
CAL40434 CAL44818 CAV31018 CAX87027 CBX74361 CBX78818 EAW49037 EAW49038 Q969D9 AF338732 AAK60617 AL833421 AY037115 AAK67490 BC016720 AAH16720 BC022894 AAH22894 BC040592 AAH40592 BF245025 BU571002 XM_011543698 XP_011542000 NM_033035 NP_149024 NM_138551 NP_612561 NR_045089
|
| Function |
Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269|PubMed:11418668, ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:17242164}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:11418668}.
|
| Tissue Specificity |
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva. {ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:24850429}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|