Gene Symbol | TSLP |
---|---|
Entrez Gene | 85480 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | thymic stromal lymphopoietin |
Other Description | - |
Swissprots | Q8IW99 G3XAM8 Q96AU7 Q969D9 |
Accessions | CAL40434 CAL44818 CAV31018 CAX87027 CBX74361 CBX78818 EAW49037 EAW49038 Q969D9 AF338732 AAK60617 AL833421 AY037115 AAK67490 BC016720 AAH16720 BC022894 AAH22894 BC040592 AAH40592 BF245025 BU571002 XM_011543698 XP_011542000 NM_033035 NP_149024 NM_138551 NP_612561 NR_045089 |
Function | Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269|PubMed:11418668, ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:17242164}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:11418668}. |
Tissue Specificity | Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva. {ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:24850429}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
TSLP CRISPR/Cas9 KO Plasmid (h) - sc-404546 from Santa Cruz Biotechnology
|
||||||||
TSLP HDR Plasmid (h) - sc-404546-HDR from Santa Cruz Biotechnology
|
||||||||
TSLP Double Nickase Plasmid (h) - sc-404546-NIC from Santa Cruz Biotechnology
|
||||||||
TSLP Double Nickase Plasmid (h2) - sc-404546-NIC-2 from Santa Cruz Biotechnology
|
||||||||
TSLP CRISPR Activation Plasmid (h) - sc-404546-ACT from Santa Cruz Biotechnology
|
||||||||
TSLP CRISPR Activation Plasmid (h2) - sc-404546-ACT-2 from Santa Cruz Biotechnology
|
||||||||
TSLP Lentiviral Activation Particles (h) - sc-404546-LAC from Santa Cruz Biotechnology
|
||||||||
TSLP Lentiviral Activation Particles (h2) - sc-404546-LAC-2 from Santa Cruz Biotechnology
|
||||||||
TSLP siRNA (h) - sc-45234 from Santa Cruz Biotechnology
|
||||||||
TSLP shRNA Plasmid (h) - sc-45234-SH from Santa Cruz Biotechnology
|
||||||||
TSLP shRNA (h) Lentiviral Particles - sc-45234-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU075571 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22096 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22096 from Sigma-Aldrich
|
||||||||
TSLP siRNA (Human) - CRJ3837 from Cohesion Biosciences
|
||||||||
TSLP - MBS8208307 from MyBioSource
|
||||||||
shRNA set against Human TSLP (NM_033035.4) - SHH436168 from Creative biogene
|
||||||||
TSLP shRNA Plasmid (Human) - CHJ3837 from Cohesion Biosciences
|
||||||||
TSLP miRNA 3'UTR clone - MiUTR4H-TG12700 from Creative biogene
|