Gene Symbol | MANF |
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Entrez Gene | 7873 |
Alt Symbol | ARMET, ARP |
Species | Human |
Gene Type | protein-coding |
Description | mesencephalic astrocyte-derived neurotrophic factor |
Other Description | arginine-rich, mutated in early stage tumors |
Swissprots | Q14CX4 Q86U67 P55145 Q96IS4 |
Accessions | CAH05640 EAW65138 P55145 AK292243 BAF84932 BC007282 AAH07282 BC033055 BC113588 AAI13589 BC113590 AAI13591 BE514267 BT007110 AAP35774 CN410909 CN410911 EU832655 ACE87746 EU832733 ACE87065 M83751 AAB08753 NM_006010 NP_006001 |
Function | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914}. |
ARMET-Over-expression-Lysate - LY10406a from Abgent, a WuXi AppTec company
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ARMET / ARP Lysate(Denatured) - H00007873-T01 from Acris Antibodies
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MANF 293 Cell Lysate - 401622 from ABBIOTEC
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ARMET Overexpression Lysate (Denatured) - H00007873-T01 from Novus Biologicals
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ARMET Overexpression Lysate (Native) - NBL1-07719 from Novus Biologicals
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MANF Over-expression Lysate Product - GWB-A3DAAE from Genway Biotech
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Human MANF / ARMET HEK293 Cell Lysate (WB positive control) - 15548-H02HL-300 from Sino Biological
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Human MANF / ARMET HEK293 Cell Lysate (WB positive control) - 11324-H08HL-300 from Sino Biological
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Human MANF Human Cells Transfected Lysate (positive control) (denatured) - orb233029 from Biorbyt
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Human MANF Human Cells Transfected Lysate (positive control) (denatured) - orb173540 from Biorbyt
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Panoply™ Human MANF Knockdown Stable Cell Line - CSC-DC009145 from Creative biogene
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Human MANF Knockout Cell Line-HEK293T - CSC-RT1170 from Creative biogene
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MANF KO Cell Lysate-HEK293T - CLKO-0672 from Creative biogene
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