Gene Symbol | MANF |
---|---|
Entrez Gene | 7873 |
Alt Symbol | ARMET, ARP |
Species | Human |
Gene Type | protein-coding |
Description | mesencephalic astrocyte-derived neurotrophic factor |
Other Description | arginine-rich, mutated in early stage tumors |
Swissprots | Q14CX4 Q86U67 P55145 Q96IS4 |
Accessions | CAH05640 EAW65138 P55145 AK292243 BAF84932 BC007282 AAH07282 BC033055 BC113588 AAI13589 BC113590 AAI13591 BE514267 BT007110 AAP35774 CN410909 CN410911 EU832655 ACE87746 EU832733 ACE87065 M83751 AAB08753 NM_006010 NP_006001 |
Function | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914}. |