NUAK1

Gene Symbol NUAK1
Entrez Gene 9891
Alt Symbol ARK5
Species Human
Gene Type protein-coding
Description NUAK family, SNF1-like kinase, 1
Other Description AMP-activated protein kinase family member 5|AMPK-related protein kinase 5|NUAK family SNF1-like kinase 1|omphalocele kinase 1
Swissprots A7MD39 Q96KA8 O60285
Accessions EAW97768 EAW97769 O60285 AB011109 BAA25463 AK027302 BAB55026 AK289992 BAF82681 BC152462 AAI52463 BC160165 AAI60165 BG831390 BQ694341 CK001516 R61142 NM_014840 NP_055655
Function Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser- 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppr
Subcellular Location Nucleus {ECO:0000269|PubMed:21317932}. Cytoplasm {ECO:0000269|PubMed:21317932}.
Tissue Specificity Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines. {ECO:0000269|PubMed:14982852}.

ARK5 Antibody - 4458 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from L929 and C33A cells, using ARK5 Antibody.

ARK5 (N-14) - sc-49366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ARK5 (N-14): sc-49366. Western blot analysis of ARK5 expression in non-transfected: sc-117752 (A) and human ARK5 transfected: sc-173768 (B) 293T whole cell lysates.

ARK5 (A-9) - sc-271827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARK5 (A-9): sc-271827. Western blot analysis of ARK5 expression in Hep G2 (A), Saos-2 (B) and A549 (C) whole cell lysates.

ARK5 (B-4) - sc-271828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARK5 (B-4): sc-271828. Western blot analysis of ARK5 expression in Saos-2 (A) and A549 (B) whole cell lysates.

ARK5 (D-10) - sc-393458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARK5 (D-10): sc-393458. Western blot analysis of ARK5 expression in non-transfected: sc-117752 (A) and human ARK5 transfected: sc-173768 (B) 293T whole cell lysates.

ARK5 (H-12) - sc-393459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARK5 (H-12): sc-393459. Western blot analysis of ARK5 expression in non-transfected: sc-117752 (A) and human ARK5 transfected: sc-173768 (B) 293T whole cell lysates.

ARK5 (H-136) - sc-134740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ARK5 (H-136): sc-134740. Western blot analysis of ARK5 expression in non-transfected: sc-117752 (A) and human ARK5 transfected: sc-173768 (B) 293T whole cell lysates.

ARK5 (N-19) - sc-130117 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ARK5 (N-19): sc-130117. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-ARK5 antibody - ab37641 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ARK5 antibody (ab37641) at 1/100 dilution + Mouse brain tissue lysate

Anti-ARK5 antibody - ab71814 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ARK5 antibody (ab71814) at 1/100 dilution + mouse brain tissue lysate at 12.5 µgSecondaryHRP-anti-rabbit developed using the ECL technique

Anti-ARK5 antibody - ab92275 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-ARK5 antibody (ab92275) at 1/0.3 dilution + Human kidney lysate in RIPA buffer at 35 µg

Anti-NUAK1 / ARK5 Antibody (aa4-33, APC) - LS-C251702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa4-33, Biotin) - LS-C251703 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa4-33, FITC) - LS-C251704 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa4-33, Azide-free, HRP) - LS-C252882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus, APC) - LS-C275226 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus, AP) - LS-C275225 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa4-33, PE) - LS-C252883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus, FITC) - LS-C275228 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus, Biotin) - LS-C275227 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus, Azide-free, HRP) - LS-C275229 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa64-113) - LS-C151797 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NUAK1 / ARK5 antibody Western Blot of HepG2.

Anti-NUAK1 / ARK5 Antibody (C-Terminus, PE) - LS-C275231 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (aa4-33) - LS-C319592 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NUAK1 / ARK5 Antibody (C-Terminus) - LS-C326871 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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