| Gene Symbol |
NUAK1
|
| Entrez Gene |
9891
|
| Alt Symbol |
ARK5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NUAK family, SNF1-like kinase, 1
|
| Other Description |
AMP-activated protein kinase family member 5|AMPK-related protein kinase 5|NUAK family SNF1-like kinase 1|omphalocele kinase 1
|
| Swissprots |
A7MD39 Q96KA8 O60285
|
| Accessions |
EAW97768 EAW97769 O60285 AB011109 BAA25463 AK027302 BAB55026 AK289992 BAF82681 BC152462 AAI52463 BC160165 AAI60165 BG831390 BQ694341 CK001516 R61142 NM_014840 NP_055655
|
| Function |
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser- 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppr
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21317932}. Cytoplasm {ECO:0000269|PubMed:21317932}.
|
| Tissue Specificity |
Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines. {ECO:0000269|PubMed:14982852}.
|