NUAK1

Gene Symbol	NUAK1
Entrez Gene	9891
Alt Symbol	ARK5
Species	Human
Gene Type	protein-coding
Description	NUAK family, SNF1-like kinase, 1
Other Description	AMP-activated protein kinase family member 5|AMPK-related protein kinase 5|NUAK family SNF1-like kinase 1|omphalocele kinase 1
Swissprots	A7MD39 Q96KA8 O60285
Accessions	EAW97768 EAW97769 O60285 AB011109 BAA25463 AK027302 BAB55026 AK289992 BAF82681 BC152462 AAI52463 BC160165 AAI60165 BG831390 BQ694341 CK001516 R61142 NM_014840 NP_055655
Function	Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser- 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppr
Subcellular Location	Nucleus {ECO:0000269|PubMed:21317932}. Cytoplasm {ECO:0000269|PubMed:21317932}.
Tissue Specificity	Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines. {ECO:0000269|PubMed:14982852}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ARK5 full length protein - ab125626 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human ARK5 full length protein - ab160700 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human ARK5 protein fragment - ab160701 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

NUAK1 / ARK5 Antibody Blocking Peptide - LS-E23594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUAK1 / ARK5 Antibody Blocking Peptide - LS-E9465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUAK1 / ARK5 Antibody Blocking Peptide - LS-E9466 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUAK1 / ARK5 Antibody Blocking Peptide - LS-E26675 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ARK5/NUAK1 Protein - H00009891-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ARK5/NUAK1 Protein - H00009891-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ARK5/NUAK1 Recombinant Protein - P4650 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

ARK5/NUAK1 Peptide - P3060 from Novus Biologicals Category Peptide Species Human

ARK5/NUAK1 Peptide - P3059 from Novus Biologicals Category Peptide Species Human

ARK5-Antibody-C-term-Blocking-Peptide - BP8066b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARK5-Antibody-N-term-Blocking-Peptide - BP8066a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARK5 blocking peptide - GTX47589-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Rat

NUAK1 Immunizing peptide - orb55059 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ARK5 Peptide - AC21-1515-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NUAK1 / ARK5 - H00009891-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

NUAK1 / ARK5 - H00009891-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NUAK1 / ARK5 - H00009891-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NUAK1 / ARK5 - P4650 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

NUAK1 / ARK5 - P5735 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

NUAK1 Peptide - 42-035P from ProSci Category Peptide Species Human

NUAK1 fusion protein - ag18612 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NUAK1 fusion protein - Ag18832 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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