POLA1

Gene Symbol	POLA1
Entrez Gene	5422
Alt Symbol	NSX, POLA, p180
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), alpha 1, catalytic subunit
Other Description	DNA polymerase alpha 1 catalytic subunit|DNA polymerase alpha catalytic subunit|DNA polymerase alpha catalytic subunit p180|DNA polymerase alpha p180 subunit|polymerase (DNA-directed), alpha (70kD)
Swissprots	P09884 Q86UQ7
Accessions	AAA52318 AAP13534 CAA47340 CAZ65678 CCQ43547 EAW99028 P09884 BM664024 BU508486 BX648513 CN364591 DW462890 X06745 CAA29920 XM_005274552 XP_005274609 XM_006724499 XP_006724562 XM_011545540 XP_011543842 XM_011545541 XP_011543843 NM_016937 NP_058633
Function	Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. {ECO:0000269|PubMed:9518481}.
Subcellular Location	Nucleus.
Top Pathways	DNA replication, Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLA1 / DNA Polymerase Alpha 1 ELISA Kit (Cell-Based ELISA) - LS-F3052 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-PolA1 Antibody, Affinity Purified - PLA0270 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

polymerase (DNA directed) , alpha 1, catalytic subunit, ELISA Kit - MBS9318825 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Polymerase alpha Colorimetric Cell-Based ELISA - CB5835 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human POLA1 ELISA Kit - E030088 from Biobool Category ELISA Kit

DNA polymerase alpha catalytic subunit, ELISA Kit - MBS285480 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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