POLA1

Gene Symbol	POLA1
Entrez Gene	5422
Alt Symbol	NSX, POLA, p180
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), alpha 1, catalytic subunit
Other Description	DNA polymerase alpha 1 catalytic subunit|DNA polymerase alpha catalytic subunit|DNA polymerase alpha catalytic subunit p180|DNA polymerase alpha p180 subunit|polymerase (DNA-directed), alpha (70kD)
Swissprots	P09884 Q86UQ7
Accessions	AAA52318 AAP13534 CAA47340 CAZ65678 CCQ43547 EAW99028 P09884 BM664024 BU508486 BX648513 CN364591 DW462890 X06745 CAA29920 XM_005274552 XP_005274609 XM_006724499 XP_006724562 XM_011545540 XP_011543842 XM_011545541 XP_011543843 NM_016937 NP_058633
Function	Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. {ECO:0000269|PubMed:9518481}.
Subcellular Location	Nucleus.
Top Pathways	DNA replication, Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNA polymerase alpha peptide - ab30406 from Abcam Category Peptide

Human DNA polymerase alpha protein fragment - ab114839 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human DNA polymerase alpha Protein - H00005422-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

E.coli polA protein - orb245659 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg

E.coli polA protein - orb246706 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

E.coli polA protein - orb245657 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

E.coli polA protein - orb245658 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg

E.coli polA protein - orb245656 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

POLA1 - H00005422-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POLA1 - H00005422-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human POLA1 - POLA1-28359TH from Creative Biomart Category Protein Source Wheat germ

DNA Polymerase alpha 1 Blocking Peptide - CBP1906 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

DNA pol α (K111) Peptide - BS1922P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant thermus aquacicus DNA polymerase I, thermostable - CSB-EP166644Ba(S9) CSB-BP166644Ba(S9) CSB-MP166644Ba(S9) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell

Recombinant thermus aquacicus DNA polymerase I, thermostable - CSB-EP166624Ba(s7) CSB-BP166624Ba(s7) CSB-MP166624Ba(s7) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell

Recombinant thermus aquacicus DNA polymerase I, thermostable - CSB-EP166644Ba(A5) CSB-BP166644Ba(A5) CSB-MP166644Ba(A5) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell

Recombinant thermus aquacicus DNA polymerase I, thermostable - CSB-EP166674Ba(A5) CSB-BP166674Ba(A5) CSB-MP166674Ba(A5) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell

Recombinant thermus aquacicus DNA polymerase I, thermostable - CSB-EP166674Ba(A4) CSB-BP166674Ba(A4) CSB-MP166674Ba(A4) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell

Recombinant Thermus aquaticus DNA polymerase I, thermostable(polA),partial - CSB-RP166644Ba(S9) from Cusabio Category Protein Source E.coli

Recombinant Thermus aquaticus DNA polymerase I, thermostable(polA),partial - CSB-RP166624Ba(s7) from Cusabio Category Protein Source E.coli

Recombinant Thermus aquaticus DNA polymerase I, thermostable(polA),partial - CSB-RP166644Ba(A5) from Cusabio Category Protein Source E.coli

Recombinant Thermus aquaticus DNA polymerase I, thermostable(polA),partial - CSB-RP166674Ba(A5) from Cusabio Category Protein Source E.coli

Recombinant Thermus aquaticus DNA polymerase I, thermostable(polA),partial - CSB-RP166674Ba(A4) from Cusabio Category Protein Source E.coli

Recombinant Human DNA polymerase alpha catalytic subunit(POLA1) ,partial - CSB-YP018300HU CSB-EP018300HU CSB-BP018300HU CSB-MP018300HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Polymerase DNA Directed Alpha 1 (POLa1) - RPC713Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Search more