| Gene Symbol |
FIS1
|
| Entrez Gene |
51024
|
| Alt Symbol |
CGI-135, TTC11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
|
| Other Description |
FIS1 homolog|H_NH0132A01.6|TPR repeat protein 11|hFis1|mitochondrial fission 1 protein|tetratricopeptide repeat domain 11|tetratricopeptide repeat protein 11
|
| Swissprots |
Q9BTP3 Q9Y3D6
|
| Accessions |
AAP22366 EAW50212 EAW50213 EAW50214 Q9Y3D6 AF151893 AAD34130 AK310968 AK311665 BC003540 AAH03540 BC009428 AAH09428 BI836529 HQ448311 ADQ32791 NM_016068 NP_057152
|
| Function |
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}.
|
| Subcellular Location |
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
|
