FIS1

Gene Symbol FIS1
Entrez Gene 51024
Alt Symbol CGI-135, TTC11
Species Human
Gene Type protein-coding
Description fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Other Description FIS1 homolog|H_NH0132A01.6|TPR repeat protein 11|hFis1|mitochondrial fission 1 protein|tetratricopeptide repeat domain 11|tetratricopeptide repeat protein 11
Swissprots Q9BTP3 Q9Y3D6
Accessions AAP22366 EAW50212 EAW50213 EAW50214 Q9Y3D6 AF151893 AAD34130 AK310968 AK311665 BC003540 AAH03540 BC009428 AAH09428 BI836529 HQ448311 ADQ32791 NM_016068 NP_057152
Function Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}.
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Fis1 (B-5) - sc-376447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fis1 (B-5): sc-376447. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Fis1 (C-10) - sc-376469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fis1 (C-10): sc-376469. Western blot analysis of Fis1 expression in A-431 (A) and HeLa (B) whole cell lysates.

Fis1 (D-9) - sc-376446 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fis1 (D-9): sc-376446. Western blot analysis of Fis1 expression in A-431 (A) and HeLa (B) whole cell lysates.

Fis1 (K-14) - sc-48865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fis1 (K-14): sc-48865. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Fis1 (FL-152) - sc-98900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fis1 (FL-152): sc-98900. Western blot analysis of Fis1 expression in A-431 (A) and HeLa (B) whole cell lysates.

Anti-TTC11 antibody - ab71498 from Abcam

Prices $382.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TTC11 antibody (ab71498) at 1 µg/mlLane 1 : Jurkat cell lysatesLane 2 : Jurkat cell lysates

Anti-TTC11 antibody - ab89514 from Abcam

Host Mouse
Clonality Monoclonal
Anti-TTC11 antibody (ab89514) at 1/500 dilution + immunogen (full length recombinant protein with a tag of 26kDa) at 0.2 µg

Anti-TTC11 antibody - ab24242 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FIS1 Antibody - LS-C334315 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using FIS1 antibody. Blue: DAPI for nuclear staining.

Anti-FIS1 Antibody (clone 1G9) - LS-C105139 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1G9
FIS1 monoclonal antibody (M01), clone 1G9. Western blot of FIS1 expression in human liver.

Anti-FIS1 Antibody IHC-plus™ - LS-B627 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FIS1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B627 dilution 1:500.

Anti-FIS1 Antibody IHC-plus™ - LS-B8740 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FIS1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FIS1 Antibody - LS-C344841 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Localization of endogenous human Fis1 in HeLa cells. Method: Double staining with mtHSP70, mAb (JG1) [left] and using anti-Fis1, pAb [right] on methanol fixed cells reveals mitochondrial localization.

Anti-FIS1 Antibody (aa11-25) IHC-plus™ - LS-B6502 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FIS1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6502 concentration 5 ug/ml.

Anti-FIS1 Antibody (aa6-40) - LS-C344302 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from Raji cell line, human spleen, mouse brain and rat brain tissue lysate (from left to right) with FIS1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-FIS1 Antibody (aa1-152) - LS-C186184 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded NCIN87 xenograft using FIS1 antibody at 1:100 dilution.

Anti-FIS1 Antibody (N-Terminus) - LS-C46945 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FIS1 Antibody - LS-C146917 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FIS1 Antibody - LS-C341890 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TTC11 Antibody - NB100-56646 from Novus Biologicals

Prices $99.00, $299.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 cells stably transfected with vector only, Fis1 RNAi, Fis1 (Fis1wt OE) or left untransfected (negative control). The western blot data showed that M17 cells expressed Fis1 (Vector, Untransfected control) which could be knocked down by Fis1 RNAi. Cells transfected with Fis1 overexpressed Fis1. M17 is a human neuroblastoma cell line.

TTC11 Antibody (1G9) - H00051024-M01 from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1G9
Western Blot: TTC11 Antibody (1G9) [H00051024-M01] - FIS1 monoclonal antibody (M01), clone 1G9. Western Blot analysis of FIS1 expression in human liver.

TTC11 Antibody - NBP1-85664 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TTC11 Antibody [NBP1-85664] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

TTC11 Antibody (1G9) - H00051024-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1G9
Western Blot: TTC11 Antibody (1G9) [H00051024-M01A] - FIS1 monoclonal antibody (M01), clone 1G9. Western Blot analysis of FIS1 expression in human liver.

TTC11 Antibody (3G6) - H00051024-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G6
Western Blot: TTC11 Antibody (3G6) [H00051024-M02] - FIS1 monoclonal antibody (M02), clone 3G6. Analysis of FIS1 expression in MCF-7.

TTC11 Antibody - H00051024-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TTC11 Antibody [H00051024-A01] - TTC11 polyclonal antibody (A01), Lot # 051206JC01 Western Blot analysis of FIS1 expression in MES-SA/Dx5 ( Cat # L021V1 ).
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