Gene Symbol | FIS1 |
---|---|
Entrez Gene | 51024 |
Alt Symbol | CGI-135, TTC11 |
Species | Human |
Gene Type | protein-coding |
Description | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) |
Other Description | FIS1 homolog|H_NH0132A01.6|TPR repeat protein 11|hFis1|mitochondrial fission 1 protein|tetratricopeptide repeat domain 11|tetratricopeptide repeat protein 11 |
Swissprots | Q9BTP3 Q9Y3D6 |
Accessions | AAP22366 EAW50212 EAW50213 EAW50214 Q9Y3D6 AF151893 AAD34130 AK310968 AK311665 BC003540 AAH03540 BC009428 AAH09428 BI836529 HQ448311 ADQ32791 NM_016068 NP_057152 |
Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}. |
Subcellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. |