| Gene Symbol |
ANP32B
|
| Entrez Gene |
10541
|
| Alt Symbol |
APRIL, PHAPI2, SSP29
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
|
| Other Description |
acidic leucine-rich nuclear phosphoprotein 32 family member B|acidic protein rich in leucines|putative HLA-DR-associated protein I-2|silver-stainable protein SSP29
|
| Swissprots |
Q92688 P78458 B2R9C7 P78459 O00655
|
| Accessions |
EAW58864 EAW58865 Q92688 AK223454 BAD97174 AK313733 BAG36474 AW296974 BC013003 AAH13003 BC019658 AAH19658 BP395780 U70439 AAB37579 Y07569 CAA68855 Y07570 CAA68856 Y07969 CAA69265 NM_006401 NP_006392
|
| Function |
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}.
|
| Subcellular Location |
Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. {ECO:0000269|PubMed:9473664}.
|
![Western Blot: ANP32B Overexpression Lysate (Adult Normal) [NBL1-07551] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ANP32B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10991_ANP32B%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07551-img0002.jpg)