Gene Symbol | ANP32B |
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Entrez Gene | 10541 |
Alt Symbol | APRIL, PHAPI2, SSP29 |
Species | Human |
Gene Type | protein-coding |
Description | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
Other Description | acidic leucine-rich nuclear phosphoprotein 32 family member B|acidic protein rich in leucines|putative HLA-DR-associated protein I-2|silver-stainable protein SSP29 |
Swissprots | Q92688 P78458 B2R9C7 P78459 O00655 |
Accessions | EAW58864 EAW58865 Q92688 AK223454 BAD97174 AK313733 BAG36474 AW296974 BC013003 AAH13003 BC019658 AAH19658 BP395780 U70439 AAB37579 Y07569 CAA68855 Y07570 CAA68856 Y07969 CAA69265 NM_006401 NP_006392 |
Function | Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}. |
Subcellular Location | Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}. |
Tissue Specificity | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. {ECO:0000269|PubMed:9473664}. |
ANP32B CRISPR/Cas9 KO Plasmid (h) - sc-417840 from Santa Cruz Biotechnology
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ANP32B HDR Plasmid (h) - sc-417840-HDR from Santa Cruz Biotechnology
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ANP32B Double Nickase Plasmid (h) - sc-417840-NIC from Santa Cruz Biotechnology
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ANP32B Double Nickase Plasmid (h2) - sc-417840-NIC-2 from Santa Cruz Biotechnology
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ANP32B CRISPR Activation Plasmid (h) - sc-417840-ACT from Santa Cruz Biotechnology
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ANP32B CRISPR Activation Plasmid (h2) - sc-417840-ACT-2 from Santa Cruz Biotechnology
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ANP32B Lentiviral Activation Particles (h) - sc-417840-LAC from Santa Cruz Biotechnology
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ANP32B Lentiviral Activation Particles (h2) - sc-417840-LAC-2 from Santa Cruz Biotechnology
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ANP32B siRNA (h) - sc-62796 from Santa Cruz Biotechnology
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ANP32B shRNA Plasmid (h) - sc-62796-SH from Santa Cruz Biotechnology
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ANP32B shRNA (h) Lentiviral Particles - sc-62796-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU055901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3251 from Sigma-Aldrich
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ANP32B siRNA (Human) - CRH7166 from Cohesion Biosciences
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ANP32B - MBS8224467 from MyBioSource
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shRNA set against Human ANP32B(NM_006401.2) - SHG061363 from Creative biogene
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ANP32B shRNA Plasmid (Human) - CHH7166 from Cohesion Biosciences
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ANP32B miRNA 3'UTR clone - MiUTR1H-00416 from Creative biogene
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