| Gene Symbol | RAP1B |
|---|---|
| Entrez Gene | 5908 |
| Alt Symbol | K-REV, RAL1B |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAP1B, member of RAS oncogene family |
| Other Description | GTP-binding protein smg p21B|RAS-related protein RAP1B|Ras family small GTP binding protein RAP1B|ras-related protein Rap-1b|small GTP binding protein |
| Swissprots | Q502X3 B4DW74 Q6DCA1 B4DW94 Q6LES0 P61224 B2R5Z2 Q5TZR4 B4DQI8 |
| Accessions | ABQ52130 CAA00805 EAW97189 EAW97190 EAW97191 EAW97192 EAW97193 P61224 AA809981 AB062128 BAB93460 AF279894 AAK07551 AF493913 AAM12627 AJ420497 AK127392 AK298818 BAG60950 AK301401 BAG62936 AK301428 BAG62956 AK311559 AK312371 BAG35289 AK316447 BAH14818 AK316543 BAH14914 AL080212 CAB45777 AM393243 CAL38121 BC000176 AAH00176 BC078173 AAH78173 BC095467 AAH95467 BG717530 BT020093 AAV38896 CR407689 CAG28617 CX868584 DB448914 DQ583925 X08004 CAB46488 NM_001010942 NP_001010942 NM_001251917 NP_001238846 NM_001251918 NP_001238847 NM_001251921 NP_001238850 NM_001251922 NP_001238851 NM_015646 NP_056461 |
| Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}. |
| Subcellular Location | Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction. |
| Top Pathways | Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway |
Rap 1B CRISPR/Cas9 KO Plasmid (h) - sc-417913 from Santa Cruz Biotechnology
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Rap 1B HDR Plasmid (h) - sc-417913-HDR from Santa Cruz Biotechnology
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Rap 1B Double Nickase Plasmid (h) - sc-417913-NIC from Santa Cruz Biotechnology
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Rap 1B Double Nickase Plasmid (h2) - sc-417913-NIC-2 from Santa Cruz Biotechnology
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Rap 1B CRISPR Activation Plasmid (h) - sc-417913-ACT from Santa Cruz Biotechnology
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Rap 1B CRISPR Activation Plasmid (h2) - sc-417913-ACT-2 from Santa Cruz Biotechnology
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Rap 1B Lentiviral Activation Particles (h) - sc-417913-LAC from Santa Cruz Biotechnology
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Rap 1B Lentiviral Activation Particles (h2) - sc-417913-LAC-2 from Santa Cruz Biotechnology
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Rap 1B siRNA (h) - sc-41854 from Santa Cruz Biotechnology
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Rap 1B shRNA Plasmid (h) - sc-41854-SH from Santa Cruz Biotechnology
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Rap 1B shRNA (h) Lentiviral Particles - sc-41854-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU107691 from Sigma-Aldrich
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MISSION® esiRNA - EHU116101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17946 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17946 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09116 from Sigma-Aldrich
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RAP1B siRNA (Human) - CRH3994 from Cohesion Biosciences
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RAP1B - MBS8220044 from MyBioSource
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shRNA set against Human RAP1B (NM_015646.5) - SHH389576 from Creative biogene
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Human RAP1B siRNA - orb264496 from Biorbyt
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RAP1B shRNA Plasmid (Human) - CHH3994 from Cohesion Biosciences
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RAP1B miRNA 3'UTR clone - MiUTR3H-01989 from Creative biogene
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RAP1B miRNA 3'UTR clone - MiUTR3H-01990 from Creative biogene
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