Gene Symbol | RAP1B |
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Entrez Gene | 5908 |
Alt Symbol | K-REV, RAL1B |
Species | Human |
Gene Type | protein-coding |
Description | RAP1B, member of RAS oncogene family |
Other Description | GTP-binding protein smg p21B|RAS-related protein RAP1B|Ras family small GTP binding protein RAP1B|ras-related protein Rap-1b|small GTP binding protein |
Swissprots | Q502X3 B4DW74 Q6DCA1 B4DW94 Q6LES0 P61224 B2R5Z2 Q5TZR4 B4DQI8 |
Accessions | ABQ52130 CAA00805 EAW97189 EAW97190 EAW97191 EAW97192 EAW97193 P61224 AA809981 AB062128 BAB93460 AF279894 AAK07551 AF493913 AAM12627 AJ420497 AK127392 AK298818 BAG60950 AK301401 BAG62936 AK301428 BAG62956 AK311559 AK312371 BAG35289 AK316447 BAH14818 AK316543 BAH14914 AL080212 CAB45777 AM393243 CAL38121 BC000176 AAH00176 BC078173 AAH78173 BC095467 AAH95467 BG717530 BT020093 AAV38896 CR407689 CAG28617 CX868584 DB448914 DQ583925 X08004 CAB46488 NM_001010942 NP_001010942 NM_001251917 NP_001238846 NM_001251918 NP_001238847 NM_001251921 NP_001238850 NM_001251922 NP_001238851 NM_015646 NP_056461 |
Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}. |
Subcellular Location | Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction. |
Top Pathways | Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway |
Rap1B (36E1) Rabbit mAb - 2326 from Cell Signaling Technology
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Rap 1B (C-17) - sc-1481 from Santa Cruz Biotechnology
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Anti-RAP1B antibody - ab182606 from Abcam
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Anti-RAP1B antibody - ab123704 from Abcam
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Anti-RAP1B delta C antibody - ab94430 from Abcam
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Anti-RAP1B Antibody (aa150-178, AP) - LS-C267823 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178, APC) - LS-C267825 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178, Biotin) - LS-C267826 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178, FITC) - LS-C267827 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178, Azide-free, HRP) - LS-C267828 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa149-178) - LS-C324521 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178, PE) - LS-C267829 from LifeSpan Bioscience
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Anti-RAP1B Antibody (N-Terminus) - LS-C111835 from LifeSpan Bioscience
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Anti-RAP1B Antibody (aa150-178) - LS-C162438 from LifeSpan Bioscience
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RAP1B Antibody - NBP2-20072 from Novus Biologicals
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RAP1B Antibody - NBP1-54871 from Novus Biologicals
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RAP1B Antibody - NBP2-20071 from Novus Biologicals
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Anti-RAP1B antibody produced in rabbit - SAB2700792 from Sigma-Aldrich
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Anti-RAP1B, (N-terminal) antibody produced in rabbit - SAB2104282 from Sigma-Aldrich
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Monoclonal Anti-RAP1 A/B antibody produced in mouse - R1030 from Sigma-Aldrich
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Anti-RAP1B antibody produced in rabbit - SAB2701110 from Sigma-Aldrich
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RAP1B antibody - N-terminal region (ARP56194_P050) - ARP56194_P050 from Aviva Systems Biology
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RAP1B-Antibody-C-term - AP14852b from Abgent, a WuXi AppTec company
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RAP1B Antibody - C-terminal region (OAAB11183) - OAAB11183 from Aviva Systems Biology
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RAP1B antibody - 70R-19769 from Fitzgerald
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