| Gene Symbol |
KAT2A
|
| Entrez Gene |
2648
|
| Alt Symbol |
GCN5, GCN5L2, PCAF-b, hGCN5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
K(lysine) acetyltransferase 2A
|
| Other Description |
GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2|General control of amino acid synthesis, yeast, homolog-like 2|STAF97|general control of amino acid synthesis protein 5-like 2|histone acetyltransferase GCN5|histone acetyltransferase KAT2A|hsGCN5|lysine acetyltransferase 2A
|
| Swissprots |
Q9UCW1 Q8N1A2 Q92830
|
| Accessions |
AAC50641 EAW60801 EAW60802 EAW60803 Q92830 AF029777 AAC39769 BC032743 AAH32743 BC039907 AAH39907 BC105977 AAI05978 DB497139 XM_006721817 XP_006721880 XM_006721818 XP_006721881 NM_021078 NP_066564
|
| Function |
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11564863}.
|
| Tissue Specificity |
Expressed in all tissues tested, with most abundant expression in ovary.
|
| Top Pathways |
Notch signaling pathway, HTLV-I infection, Viral carcinogenesis
|