KAT2A

Gene Symbol KAT2A
Entrez Gene 2648
Alt Symbol GCN5, GCN5L2, PCAF-b, hGCN5
Species Human
Gene Type protein-coding
Description K(lysine) acetyltransferase 2A
Other Description GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2|General control of amino acid synthesis, yeast, homolog-like 2|STAF97|general control of amino acid synthesis protein 5-like 2|histone acetyltransferase GCN5|histone acetyltransferase KAT2A|hsGCN5|lysine acetyltransferase 2A
Swissprots Q9UCW1 Q8N1A2 Q92830
Accessions AAC50641 EAW60801 EAW60802 EAW60803 Q92830 AF029777 AAC39769 BC032743 AAH32743 BC039907 AAH39907 BC105977 AAI05978 DB497139 XM_006721817 XP_006721880 XM_006721818 XP_006721881 NM_021078 NP_066564
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11564863}.
Tissue Specificity Expressed in all tissues tested, with most abundant expression in ovary.
Top Pathways Notch signaling pathway, HTLV-I infection, Viral carcinogenesis

GCN5L2 (C26A10) Rabbit mAb - 3305 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C26A10
Western blot analysis of extracts from various cell lines using GCN5L2 (C26A10) Rabbit mAb.

GCN5 (A-11) - sc-365321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GCN5 (A-11): sc-365321. Western blot analysis of GCN5 expression in non-transfected: sc-117752 (A) and human GCN5 transfected: sc-115311 (B) 293T whole cell lysates.

GCN5 (H-75) - sc-20698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GCN5 (H-75): sc-20698. Western blot analysis of 293 cells transfected with pEBB (A), pEBB/GCN5 (B), pCMV (C) or pCMV/PCAF (D). Kindly provided by Dr. Xicheng Mao, Burstein Lab, University of Michigan.

GCN5 (C-16) - sc-6302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GCN5 (N-18) - sc-6303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ChIP analysis of transcription factor binding to the Interferon β promoter before (A) and six hours after (B) Sendai virus infection of HeLa cells. Antibodies tested included NFκB p65 (A): sc-109, ATF-2 (N-96): sc-6233, GCN5 (N-18): sc-6303, Pol II (H-224): sc-9001, TFIID (TBP)(SI-1): sc-273 and CBP (A-22): sc-369. Data kindly provided by G. Mosialos.

Anti-KAT2A / GCN5 antibody - ab18381 from Abcam

Prices $391.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab18381 at 2ug/ml staining human spleen tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). The tissue was fixed and blocked and incubated with the antibody for 30 minutes. An HRP conjugated goat antibody was used as the secondary. See Abreview

Anti-KAT2A / GCN5 antibody - ab87966 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-KAT2A / GCN5 antibody (ab87966) at 1 µg/ml + Human lung cancer lysate at 50 µgdeveloped using the ECL technique

Anti-KAT2A / GCN5 antibody - ab71227 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KAT2A / GCN5 antibody (ab71227) at 1/60 dilution + 293 cell line lysates at 35 µg

Anti-KAT2A / GCN5 antibody - ab136235 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KAT2A / GCN5 antibody (ab136235) at 1/500 dilution + RAW 264.7 cell lysate at 30 µg

Anti-KAT2A / GCN5 antibody [2384C5_2a] - ab71965 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2384C5_2a
Anti-KAT2A / GCN5 antibody [2384C5_2a] (ab71965) + immunising recombinant protein

Anti-KAT2A / GCN5 antibody [EPR12421] - ab181068 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12421
All lanes : Anti-KAT2A / GCN5 antibody [EPR12421] (ab181068) at 1/10000 dilutionLane 1 : HEK293 cell lysateLane 2 : HeLa cell lysateLane 3 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-KAT2A / GCN5 antibody - C-terminal - ab170558 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KAT2A / GCN5 antibody - C-terminal (ab170558) at 1/50 dilution + Neuro-2a cell line lysates at 35 µg

Anti-KAT2A / GCN5 Antibody - LS-C66452 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-KAT2A / GCN5 Antibody - LS-C66595 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KAT2A / GCN5 Antibody (aa411-837) - LS-C113049 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-KAT2A / GCN5 Antibody (aa65-94) - LS-C96625 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-GCN5 Antibody in 293 cell line lysates (35 ug/lane). GCN5(arrow) was detected using the purified antibody.

Anti-KAT2A / GCN5 Antibody (aa738-838, clone 10C342, Azide-free) - LS-C183646 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C342

Anti-KAT2A / GCN5 Antibody (clone 2384C5_2a) - LS-C184680 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2384C5_2a

Anti-KAT2A / GCN5 Antibody (aa611-638, AP) - LS-C215352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KAT2A / GCN5 Antibody (aa611-638, Biotin) - LS-C215354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KAT2A / GCN5 Antibody (aa611-638, APC) - LS-C215353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KAT2A / GCN5 Antibody (aa691-740) - LS-C119188 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from mouse brain cells, using GCN5L2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-KAT2A / GCN5 Antibody (Gly720) - LS-C177130 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GCN5 (G720) pAb in extracts from mouse brain.

Anti-KAT2A / GCN5 Antibody (aa611-638, PE) - LS-C215357 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KAT2A / GCN5 Antibody (aa611-638, FITC) - LS-C215355 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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