| Gene Symbol | LRWD1 |
|---|---|
| Entrez Gene | 222229 |
| Alt Symbol | CENP-33, ORCA |
| Species | Human |
| Gene Type | protein-coding |
| Description | leucine-rich repeats and WD repeat domain containing 1 |
| Other Description | ORC-associated protein|centromere protein 33|leucine-rich repeat and WD repeat-containing protein 1|origin recognition complex associated|origin recognition complex-associated protein |
| Swissprots | Q96GJ2 Q9UFC0 A8K4K2 Q8N0T9 B2R9G2 Q8WV43 |
| Accessions | EAW50250 Q9UFC0 AB209379 BAD92616 AK290967 BAF83656 AK313771 BAG36509 AL133057 CAB61382 BC009436 AAH09436 BC018769 AAH18769 BC030547 AAH30547 XM_005250204 XP_005250261 NM_152892 NP_690852 |
| Function | Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}. |
| Subcellular Location | Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3. |
| Tissue Specificity | Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO:0000269|PubMed:17074343}. |