LRWD1

Gene Symbol LRWD1
Entrez Gene 222229
Alt Symbol CENP-33, ORCA
Species Human
Gene Type protein-coding
Description leucine-rich repeats and WD repeat domain containing 1
Other Description ORC-associated protein|centromere protein 33|leucine-rich repeat and WD repeat-containing protein 1|origin recognition complex associated|origin recognition complex-associated protein
Swissprots Q96GJ2 Q9UFC0 A8K4K2 Q8N0T9 B2R9G2 Q8WV43
Accessions EAW50250 Q9UFC0 AB209379 BAD92616 AK290967 BAF83656 AK313771 BAG36509 AL133057 CAB61382 BC009436 AAH09436 BC018769 AAH18769 BC030547 AAH30547 XM_005250204 XP_005250261 NM_152892 NP_690852
Function Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}.
Subcellular Location Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Tissue Specificity Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO:0000269|PubMed:17074343}.

LRWD1 CRISPR/Cas9 KO Plasmid (h) - sc-405341 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 HDR Plasmid (h) - sc-405341-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 Double Nickase Plasmid (h) - sc-405341-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 Double Nickase Plasmid (h2) - sc-405341-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 CRISPR Activation Plasmid (h) - sc-405341-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 CRISPR Activation Plasmid (h2) - sc-405341-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 Lentiviral Activation Particles (h) - sc-405341-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 Lentiviral Activation Particles (h2) - sc-405341-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRWD1 siRNA (h) - sc-89721 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRWD1 shRNA Plasmid (h) - sc-89721-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRWD1 shRNA (h) Lentiviral Particles - sc-89721-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU130861 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12789 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12789 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LRWD1 siRNA (Human) - CRJ6558 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LRWD1 (NM_152892.1) - SHH335163 from Creative biogene

Category siRNA
Species Reactivities Human

Human LRWD1 siRNA - orb277059 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LRWD1 shRNA Plasmid (Human) - CHJ6558 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRWD1 miRNA 3'UTR clone - MiUTR1H-02845 from Creative biogene

Species Reactivities Human
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