LRWD1

Gene Symbol LRWD1
Entrez Gene 222229
Alt Symbol CENP-33, ORCA
Species Human
Gene Type protein-coding
Description leucine-rich repeats and WD repeat domain containing 1
Other Description ORC-associated protein|centromere protein 33|leucine-rich repeat and WD repeat-containing protein 1|origin recognition complex associated|origin recognition complex-associated protein
Swissprots Q96GJ2 Q9UFC0 A8K4K2 Q8N0T9 B2R9G2 Q8WV43
Accessions EAW50250 Q9UFC0 AB209379 BAD92616 AK290967 BAF83656 AK313771 BAG36509 AL133057 CAB61382 BC009436 AAH09436 BC018769 AAH18769 BC030547 AAH30547 XM_005250204 XP_005250261 NM_152892 NP_690852
Function Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}.
Subcellular Location Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Tissue Specificity Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO:0000269|PubMed:17074343}.

LRWD1 Antibody Blocking Peptide - LS-E1234 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

LRWD1-Antibody-N-term-Blocking-peptide - BP11807a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human Leucine-rich repeat and WD repeat-containing protein 1(LRWD1) - CSB-YP887017HU CSB-EP887017HU CSB-BP887017HU CSB-MP887017HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

LRWD1 - TP307141 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
LRWD1

LRWD1 Recombinant Protein Antigen - NBP1-85113PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

LRWD1 Protein - NBP1-85112PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

LRWD1 Peptide, Human - M34GP08956H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1), Recombinant Protein - MBS1471819 from MyBioSource

Category Protein
Prices $1,445.00, $1,445.00, $1,675.00, $1,675.00, $2,455.00, $2,455.00, $2,900.00, $2,900.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
Search more