| Gene Symbol |
TACR1
|
| Entrez Gene |
6869
|
| Alt Symbol |
NK1R, NKIR, SPR, TAC1R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tachykinin receptor 1
|
| Other Description |
NK-1 receptor|NK-1R|substance-P receptor|tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
|
| Swissprots |
P25103 A8K150
|
| Accessions |
AAY14950 AAY15031 CAA46292 EAW99595 EAW99596 P25103 AK289765 BAF82454 AW206679 AY462098 AAR23925 BC074911 AAH74911 BC074912 AAH74912 BC095528 AAH95528 DB203452 M74290 AAA60601 M76675 AAA59936 M81797 AAA59933 M84425 AAA36641 M84426 AAA36644 S62045 AAB20168 NM_001058 NP_001049 NM_015727 NP_056542
|
| Function |
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Calcium signaling pathway, Measles, Neuroactive ligand-receptor interaction
|