| Gene Symbol |
CBX1
|
| Entrez Gene |
10951
|
| Alt Symbol |
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromobox homolog 1
|
| Other Description |
HP1 beta homolog|chromobox homolog 1 (HP1 beta homolog Drosophila )|chromobox protein homolog 1|heterochromatin protein 1 homolog beta|heterochromatin protein 1-beta|heterochromatin protein p25 beta|modifier 1 protein
|
| Swissprots |
P23197 P83916
|
| Accessions |
AAD21972 EAW94758 EAW94759 EAW94760 EAW94761 P83916 AK312615 BAG35502 BC002609 AAH02609 BC021302 AAH21302 CB053834 CR456766 CAG33047 DA020204 DA689514 DA781730 DB026977 EU446771 ABZ92300 U35451 AAB81548 NM_001127228 NP_001120700 NM_006807 NP_006798
|
| Function |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:9169582}. Note=Unassociated with chromosomes during mitosis.
|
| Tissue Specificity |
Expressed in all adult and embryonic tissues.
|
![Western Blot: CBX1 Overexpression Lysate (Adult Normal) [NBL1-08746] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CBX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3682_CBX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08746-img0002.jpg)
![Western Blot: CBX1 Overexpression Lysate (Adult Normal) [NBP2-09436] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CBX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5345_CBX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09436-img0001.jpg)