CBX1

Gene Symbol CBX1
Entrez Gene 10951
Alt Symbol CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
Species Human
Gene Type protein-coding
Description chromobox homolog 1
Other Description HP1 beta homolog|chromobox homolog 1 (HP1 beta homolog Drosophila )|chromobox protein homolog 1|heterochromatin protein 1 homolog beta|heterochromatin protein 1-beta|heterochromatin protein p25 beta|modifier 1 protein
Swissprots P23197 P83916
Accessions AAD21972 EAW94758 EAW94759 EAW94760 EAW94761 P83916 AK312615 BAG35502 BC002609 AAH02609 BC021302 AAH21302 CB053834 CR456766 CAG33047 DA020204 DA689514 DA781730 DB026977 EU446771 ABZ92300 U35451 AAB81548 NM_001127228 NP_001120700 NM_006807 NP_006798
Function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Subcellular Location Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:9169582}. Note=Unassociated with chromosomes during mitosis.
Tissue Specificity Expressed in all adult and embryonic tissues.

HP1β (D2F2) XP ® Rabbit mAb - 8676 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2F2
Western blot analysis of extracts from various cell lines using HP1β (D2F2) XP ® Rabbit mAb.

HP1β Antibody - 2613 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, NIH/3T3, C6 and COS cells, using HP1beta Antibody.

HP1β (H-50) - sc-20699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HPIβ (H-30): sc-20699. Western blot analysis of HPIβ expression in NIH:OVCAR-3 whole cell lysate.

HP1β (C-15) - sc-10212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HP1β (C-15): sc-10212. Immunofluorescence staining of formalin-fixed HepG2 cells showing nuclear and cytoplasmic localization.

HP1β (MAC353) - sc-56704 from Santa Cruz Biotechnology

Prices $295.00
Sizes 1000 µl supernatant
Host Rat
Clonality Monoclonal
HP1β (MAC353): sc-56704. Western blot analysis of HP1β expression in A-431 (A), HeLa (B) and Hep G2 (C) nuclear extracts and C6 (D) and HeLa (E) whole cell lysates.

Anti-CBX1 / HP1 beta antibody - ab152144 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CBX1 / HP1 beta antibody (ab152144) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-CBX1 / HP1 beta antibody - ab137448 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CBX1 / HP1 beta antibody (ab137448) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-CBX1 / HP1 beta antibody [5A3] - ab101425 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5A3
All lanes : Anti-CBX1 / HP1 beta antibody [5A3] (ab101425) at 1/200 dilutionLane 1 : Hela cell lysateLane 2 : COS7 cell lysateLane 3 : NIH/3T3 cell lysateLane 4 : A431 cell lysateLane 5 : C6 cell lysate

Anti-CBX1 / HP1 beta antibody [5A3] - ab130171 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5A3
All lanes : Anti-CBX1 / HP1 beta antibody [5A3] (ab130171) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : COS7 cell lysateLane 3 : NIH3T3 cell lysateLane 4 : A431 cell lysateLane 5 : C6 cell lysate

Anti-CBX1 / HP1 beta antibody [EPR11825(B)] - ab169777 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11825(B)
All lanes : Anti-CBX1 / HP1 beta antibody [EPR11825(B)] (ab169777) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : NIH:OVCAR-3 cell lysateLane 3 : A431 cell lysateLane 4 : HeLa cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-CBX1 / HP1 beta antibody [EPR11826(B)] - ab176321 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11826(B)
All lanes : Anti-CBX1 / HP1 beta antibody [EPR11826(B)] (ab176321) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLane 3 : A431 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-CBX1 / HP1 beta antibody [MAC353] - ChIP Grade - ab10811 from Abcam

Prices $385.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone MAC353
HeLA cells were stained with ab10811 in panel one. In panel two they were stained with ab10811 (green), DAPI (blue) and SH-CREST (red), which stains the centromeres.Fix 30 minutes on ice in 4% formaldehyde in PEM. Quench autofluorescence 2 x 5 minutes with 1 mg/ml Na borohydride or 100 mM ammonium chloride in PEM. Permeablize 30 minutes with 0.5% TX-100 in PEM. Block 30 minutes in 5% milk in TBST. Primary antibody incubated overnight at 4oC diluted 1/100 in 5% milk in TBST. Secondary antibody incubated 1 hour at RT diluted in 5% milk in TBST. Post-fix 20 minutes on ice in 4% formaldehyde in PEM. Quench autofluorescence 2 x 5 minutes with ammonium chloride in PEM. Counterstain with DAPI in TBST. Mount with ProLong Gold antifade reagent from Invitrogen. Notes: Ample washing between each step. TBST = Tris buffered saline + 0.1% Tween. PEM = 80 mM K-PIPES, pH 6.8, 5 mM EGTA, 2 mM MgCl2.

Anti-CBX1 / HP1 beta antibody - ab10478 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CBX1 / HP1 beta antibody (ab10478) at 1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : HeLa nuclear lysateLane 3 : A431 cell lysateLane 4 : MCF7 cell lysateLane 5 : HEK293 cell lysateLane 6 : HeLa whole cell lysate with CBX1 / HP1 beta peptide (ab30861) at 1 µg/mlLane 7 : HeLa nuclear lysate with CBX1 / HP1 beta peptide (ab30861) at 1 µg/mlLane 8 : A431 lysate with CBX1 / HP1 beta peptide (ab30861) at 1 µg/mlLane 9 : MCF7 cell lysate with CBX1 / HP1 beta peptide (ab30861) at 1 µg/mlLane 10 : HEK293 cell lysate with CBX1 / HP1 beta peptide (ab30861) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab6721) at 1/5000 dilution

Anti-CBX1 / HP1 beta antibody - ab71635 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CBX1 / HP1 beta antibody (ab71635) at 1/100 dilution + Mouse kidney tissue lysate at 12.5 µg

Anti-CBX1 / HP1 beta antibody - ab40828 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-CBX1 / HP1 beta antibody (ab40828) at 0.3 µg/ml + A431 cell lysate at 35 µgdeveloped using the ECL technique

Anti-CBX1 / HP1 beta antibody - ab49196 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CBX1 / HP1 beta antibody (ab49196) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CBX1 / HP1 beta antibody - ab11164 from Abcam

Prices $372.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-CBX1 / HP1 Beta Antibody (aa69-81) IHC-plus™ - LS-B2395 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CBX1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2395 concentration 5 ug/ml.

Anti-CBX1 / HP1 Beta Antibody - LS-C15803 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CBX1 / HP1 Beta Antibody (C-Terminus) - LS-C15804 from LifeSpan Bioscience

Prices $590.00
Sizes 2 ml
Host Rat
Clonality Monoclonal

Anti-CBX1 / HP1 Beta Antibody - LS-C15802 from LifeSpan Bioscience

Prices $435.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-CBX1 / HP1 Beta Antibody (C-Terminus, AP) - LS-C278021 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX1 / HP1 Beta Antibody (C-Terminus, APC) - LS-C278022 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX1 / HP1 Beta Antibody (C-Terminus, Biotin) - LS-C278023 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX1 / HP1 Beta Antibody (C-Terminus, FITC) - LS-C278024 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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