| Gene Symbol | CBX1 |
|---|---|
| Entrez Gene | 10951 |
| Alt Symbol | CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromobox homolog 1 |
| Other Description | HP1 beta homolog|chromobox homolog 1 (HP1 beta homolog Drosophila )|chromobox protein homolog 1|heterochromatin protein 1 homolog beta|heterochromatin protein 1-beta|heterochromatin protein p25 beta|modifier 1 protein |
| Swissprots | P23197 P83916 |
| Accessions | AAD21972 EAW94758 EAW94759 EAW94760 EAW94761 P83916 AK312615 BAG35502 BC002609 AAH02609 BC021302 AAH21302 CB053834 CR456766 CAG33047 DA020204 DA689514 DA781730 DB026977 EU446771 ABZ92300 U35451 AAB81548 NM_001127228 NP_001120700 NM_006807 NP_006798 |
| Function | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:9169582}. Note=Unassociated with chromosomes during mitosis. |
| Tissue Specificity | Expressed in all adult and embryonic tissues. |
HP1β siRNA (h) - sc-35587 from Santa Cruz Biotechnology
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HP1β shRNA Plasmid (h) - sc-35587-SH from Santa Cruz Biotechnology
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HP1β shRNA (h) Lentiviral Particles - sc-35587-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5425 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5425 from Sigma-Aldrich
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CBX1 siRNA (Human) - CRH7473 from Cohesion Biosciences
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CBX1 - MBS8223247 from MyBioSource
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CBX1 shRNA Plasmid (Human) - CHH7473 from Cohesion Biosciences
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CBX1 miRNA 3'UTR clone - MiUTR3H-06872 from Creative biogene
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CBX1 miRNA 3'UTR clone - MiUTR3H-06873 from Creative biogene
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