| Gene Symbol |
PAPD7
|
| Entrez Gene |
11044
|
| Alt Symbol |
LAK-1, LAK1, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PAP associated domain containing 7
|
| Other Description |
DNA polymerase kappa|DNA polymerase sigma|PAP-associated domain-containing protein 7|TRAMP-like complex polyadenylate polymerase|TUTase 5|non-canonical poly(A) RNA polymerase PAPD7|polymerase (DNA directed) sigma|polymerase (DNA-directed) sigma|terminal uridylyltransferase 5|topoisomerase-related function protein 4-1
|
| Swissprots |
Q17RZ1 A8K1E2 Q5XG87 M1JCE6 Q9Y6C1 O43289
|
| Accessions |
AAT38110 EAX08101 Q5XG87 AB005754 BAA24434 AF089896 AAD45198 AI871781 AK289857 BAF82546 AK303516 BAG64545 AK308405 BC084567 AAH84567 BC117137 AAI17138 BC126106 AAI26107 BC143882 AAI43883 HQ258305 ADR83059 KC424495 AGE92663 R49553 XM_005248234 XP_005248291 XM_011513945 XP_011512247 XM_011513946 XP_011512248 XM_011513947 XP_011512249 NM_001171805 NP_001165276 NM_001171806 NP_001165277 NM_006999 NP_008930
|
| Function |
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269|PubMed:23376078}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.
|
| Top Pathways |
RNA degradation
|
![Western Blot: DNA polymerase sigma Overexpression Lysate (Adult Normal) [NBP2-10388] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA polymerase sigma.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2204_DNA%2520polymerase%2520sigma%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10388-img0001.jpg)