PAPD7

Gene Symbol PAPD7
Entrez Gene 11044
Alt Symbol LAK-1, LAK1, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5
Species Human
Gene Type protein-coding
Description PAP associated domain containing 7
Other Description DNA polymerase kappa|DNA polymerase sigma|PAP-associated domain-containing protein 7|TRAMP-like complex polyadenylate polymerase|TUTase 5|non-canonical poly(A) RNA polymerase PAPD7|polymerase (DNA directed) sigma|polymerase (DNA-directed) sigma|terminal uridylyltransferase 5|topoisomerase-related function protein 4-1
Swissprots Q17RZ1 A8K1E2 Q5XG87 M1JCE6 Q9Y6C1 O43289
Accessions AAT38110 EAX08101 Q5XG87 AB005754 BAA24434 AF089896 AAD45198 AI871781 AK289857 BAF82546 AK303516 BAG64545 AK308405 BC084567 AAH84567 BC117137 AAI17138 BC126106 AAI26107 BC143882 AAI43883 HQ258305 ADR83059 KC424495 AGE92663 R49553 XM_005248234 XP_005248291 XM_011513945 XP_011512247 XM_011513946 XP_011512248 XM_011513947 XP_011512249 NM_001171805 NP_001165276 NM_001171806 NP_001165277 NM_006999 NP_008930
Function Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269|PubMed:23376078}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.
Top Pathways RNA degradation

TRF4 (C-12) - sc-107305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRF4 (C-12): sc-107305. Western blot analysis of TRF4 expression in HeLa (A) and Hep G2 (B) nuclear extracts and MCF7 (C), A549 (D) and MDA-MB-468 (E) whole cell lysates.

TRF4 (H-172) - sc-98490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TRF4 (P-17) - sc-107307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRF4 (P-17): sc-107307. Western blot analysis of TRF4 expression in MDA-MB-468 whole cell lysate.

TRF4 (2794C4a) - sc-81637 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TRF4 (2794C4a): sc-81637. Western Blot analysis of human recombinant TRF4 fusion protein.

Anti-TRF41 antibody - ab79015 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab79015, at 5µg/ml, staining TRF41 in human thyroid tissue by Immunohistochemistry using paraffin-embedded tissue.

Anti-TRF41 antibody - ab172676 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TRF41 antibody (ab172676) at 1 µg/mlLane 1 : TRF41 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryLane 1 : Goat Anti-Mouse IgG (H&L)-HRP at 2500 Lane 2 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-TRF41 antibody - ab56847 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56847 TRF41 antibody at 1ug/ml.

Anti-PAPD7 / TRF4-1 Antibody (clone 2794C4a) - LS-C184464 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2794C4a

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, AP) - LS-C266707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, APC) - LS-C266708 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, Biotin) - LS-C266709 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, FITC) - LS-C266710 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa151-180) - LS-C324179 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, Azide-free, HRP) - LS-C266711 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa152-180, PE) - LS-C266712 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody (aa51-100) - LS-C81285 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PAPD7 / TRF4-1 Antibody (clone 2794C4a) - LS-C342504 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2794C4a
Western blot analysis of immunized recombinant protein, using anti-POLS monoclonal antibody.

Anti-PAPD7 / TRF4-1 Antibody (aa152-180) - LS-C163860 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
POLS Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The POLS antibody detected the POLS protein (arrow).

Anti-PAPD7 / TRF4-1 Antibody (aa447-462) IHC-plus™ - LS-B1981 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PAPD7 / POLS antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1981 concentration 5 ug/ml.

Anti-PAPD7 / TRF4-1 Antibody (aa447-462) - LS-C89684 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAPD7 / TRF4-1 Antibody - LS-C75016 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

DNA polymerase sigma Antibody - NB100-56356 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DNA polymerase sigma Antibody [NB100-56356] - Analysis of DNA polymerase sigma in HeLa cell lysate using NB100-56356 at A) 2 ug/ml and B) 5 ug/ml.

DNA polymerase sigma Antibody - NBP2-13729 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DNA polymerase sigma Antibody - NBP1-58159 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DNA polymerase sigma Antibody [NBP1-58159] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

DNA polymerase sigma Antibody - NBP2-13728 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DNA polymerase sigma Antibody [NBP2-13728] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp
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