L3MBTL1

Gene Symbol L3MBTL1
Entrez Gene 26013
Alt Symbol H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3
Species Human
Gene Type protein-coding
Description l(3)mbt-like 1 (Drosophila)
Other Description l(3)mbt protein homolog|lethal (3) malignant brain tumor l(3)|lethal(3)malignant brain tumor-like protein 1
Swissprots Q9UJB9 Q9H1E6 Q9H1G5 E1P5W7 Q5H8Y8 Q9Y4C9 B4DRC9 Q8IUV7 Q9UG06 Q5H8Y9 Q9Y468
Accessions EAW75957 EAW75958 EAW75959 EAW75960 EAW75961 EAW75962 Q9Y468 AB014581 BAA31656 AK123176 BAC85548 AK299199 BAG61241 AK308334 AK310345 AL110279 CAB53714 BC034398 BC039820 AAH39820 BG956397 BI040370 BU741824 DA204976 DR003568 EU446490 ABZ92019 R42592 NM_015478 NP_056293 NM_032107 NP_115479
Function Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18408754, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:20870
Subcellular Location Nucleus {ECO:0000269|PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
Tissue Specificity Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. {ECO:0000269|PubMed:10445843}.

L3MBTL (D-9) - sc-166905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L3MBTL (D-9): sc-166905. Western blot analysis of L3MBTL expression in non-transfected: sc-117752 (A) and human L3MBTL transfected: sc-115550 (B) 293T whole cell lysates.

L3MBTL (D-10) - sc-398603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L3MBTL (D-10): sc-398603. Western blot analysis of L3MBTL expression in non-transfected: sc-117752 (A) and human L3MBTL transfected: sc-115550 (B) 293T whole cell lysates.

L3MBTL (C-20) - sc-50038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L3MBTL (C-20): sc-50038. Western blot analysis of L3MBTL expression in HEL 92.1.7 (A), CCRF-CEM (B) and SK-N-MC (C) nuclear extracts and U-87 MG whole cell lysate (D).

L3MBTL (H-85) - sc-98449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
L3MBTL (H-85): sc-98449. Western blot analysis of L3MBTL expression in non-transfected: sc-117752 (A) and human L3MBTL transfected: sc-115550 (B) 293T whole cell lysates and KNRK nuclear extract (C).

L3MBTL (S-18) - sc-50040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L3MBTL (S-18): sc-50040. Western blot analysis of L3MBTL expression in HEL 92.1.7 (A), CCRF-CEM (B) and SK-N-MC (C) nuclear extracts and U-87 MG whole cell lysate (D).

L3MBTL (K-18) - sc-50039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L3MBTL (K-18): sc-50039. Western blot analysis of L3MBTL expression in non-transfected: sc-117752 (A) and human L3MBTL transfected: sc-115550 (B) 293T whole cell lysates.

L3MBTL (V-18) - sc-50041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L3MBTL (V-18): sc-50041. Western blot analysis of L3MBTL expression in HEL 92.1.7 (A), CCRF-CEM (B) and SK-N-MC (C) nuclear extracts.

Anti-L3MBTL1 antibody - ab97304 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-L3MBTL1 antibody (ab97304) at 1/1000 dilution + Hela S3 whole cell lysate at 30 µg

Anti-L3MBTL1 antibody - ab167285 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-L3MBTL1 antibody (ab167285) at 1 µg/mlLane 1 : Transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP at 1/2500 dilution

Anti-L3MBTL1 antibody - ab85463 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-L3MBTL1 antibody (ab85463) at 1 µg/ml + Human fetal brain lysate at 10 µgSecondaryanti-Rabbit IgG HRP at 1/50000 dilution

Anti-L3MBTL1 antibody - ab93389 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-L3MBTL1 antibody - ChIP Grade - ab51880 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-L3MBTL1 antibody - ChIP Grade (ab51880) at 1/2000 dilution + Nuclear extract of HeLa cells at 20 µg

Anti-L3MBTL1 Antibody - LS-C155438 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using L3MBTL antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with alpha-tubulin antibody (Red) at 1:2000.

Anti-L3MBTL1 Antibody (aa365-723) - LS-C185565 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed HeLa using L3MBTL antibody at 1:200 dilution.

Anti-L3MBTL1 Antibody - LS-C308701 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-L3MBTL1 Antibody (N-Terminus) - LS-C347731 from LifeSpan Bioscience

Prices $435.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-L3MBTL1 Antibody (N-Terminus) - LS-C346047 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of LMBL1 Antibody with human MCF7 Whole Cell lysate.

Anti-L3MBTL1 Antibody (N-Terminus) - LS-C101657 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
L3MBTL1 / L3MBTL antibody LS-C101657 Western blot of Fetal Brain lysate.

Anti-L3MBTL1 Antibody (aa144-193) - LS-C110092 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
L3MBTL1 / L3MBTL antibody LS-C110092 Western blot of 293T cell lysate.

Anti-L3MBTL1 Antibody (aa221-270) - LS-C116145 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
L3MBTL1 / L3MBTL antibody LS-C116145 Western blot of Mouse Small Intestine lysate.

Anti-L3MBTL1 Antibody (aa442-491) - LS-C116144 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
L3MBTL1 / L3MBTL antibody LS-C116144 Western blot of Mouse Kidney lysate.

Anti-L3MBTL1 Antibody - LS-C346223 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of A549 cell using L3MBTL1 antibody.

L3MBTL1 Antibody - NBP1-32447 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: L3MBTL1 Antibody [NBP1-32447] - Sample(30 ug whole cell lysate)A:HeLa S3(GTX14654)7. 5% SDS PAGE, antibody diluted at 1:1000.

L3MBTL1 Antibody - NBP2-19317 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: L3MBTL1 Antibody [NBP2-19317] - Sample (30 ug of whole cell lysate) A: HeLa nucleus 7. 5% SDS PAGE gel, diluted at 1:1000.

L3MBTL1 Antibody - H00026013-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: L3MBTL1 Antibody [H00026013-B01P] - Analysis of L3MBTL expression in transfected 293T cell line by L3MBTL polyclonal antibody. Lane 1: L3MBTL transfected lysate(84.92 KDa). Lane 2: Non-transfected lysate.
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