| Gene Symbol |
L3MBTL1
|
| Entrez Gene |
26013
|
| Alt Symbol |
H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
l(3)mbt-like 1 (Drosophila)
|
| Other Description |
l(3)mbt protein homolog|lethal (3) malignant brain tumor l(3)|lethal(3)malignant brain tumor-like protein 1
|
| Swissprots |
Q9UJB9 Q9H1E6 Q9H1G5 E1P5W7 Q5H8Y8 Q9Y4C9 B4DRC9 Q8IUV7 Q9UG06 Q5H8Y9 Q9Y468
|
| Accessions |
EAW75957 EAW75958 EAW75959 EAW75960 EAW75961 EAW75962 Q9Y468 AB014581 BAA31656 AK123176 BAC85548 AK299199 BAG61241 AK308334 AK310345 AL110279 CAB53714 BC034398 BC039820 AAH39820 BG956397 BI040370 BU741824 DA204976 DR003568 EU446490 ABZ92019 R42592 NM_015478 NP_056293 NM_032107 NP_115479
|
| Function |
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18408754, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:20870
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
|
| Tissue Specificity |
Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. {ECO:0000269|PubMed:10445843}.
|
![Western Blot: L3MBTL1 Overexpression Lysate (Adult Normal) [NBP2-07169] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for L3MBTL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8638_L3MBTL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07169-img0001.jpg)