L3MBTL1

Gene Symbol L3MBTL1
Entrez Gene 26013
Alt Symbol H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3
Species Human
Gene Type protein-coding
Description l(3)mbt-like 1 (Drosophila)
Other Description l(3)mbt protein homolog|lethal (3) malignant brain tumor l(3)|lethal(3)malignant brain tumor-like protein 1
Swissprots Q9UJB9 Q9H1E6 Q9H1G5 E1P5W7 Q5H8Y8 Q9Y4C9 B4DRC9 Q8IUV7 Q9UG06 Q5H8Y9 Q9Y468
Accessions EAW75957 EAW75958 EAW75959 EAW75960 EAW75961 EAW75962 Q9Y468 AB014581 BAA31656 AK123176 BAC85548 AK299199 BAG61241 AK308334 AK310345 AL110279 CAB53714 BC034398 BC039820 AAH39820 BG956397 BI040370 BU741824 DA204976 DR003568 EU446490 ABZ92019 R42592 NM_015478 NP_056293 NM_032107 NP_115479
Function Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18408754, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:20870
Subcellular Location Nucleus {ECO:0000269|PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
Tissue Specificity Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. {ECO:0000269|PubMed:10445843}.

Human L3MBTL1 full length protein - ab161870 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161870 on a 12.5% SDS-PAGE stained with Coomassie Blue.

L3MBTL1 Antibody Blocking Peptide - LS-E12786 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

L3MBTL1 Antibody Blocking Peptide - LS-E13504 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

L3MBTL1 Antibody Blocking Peptide - LS-E13543 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human L3MBTL1 Protein - H00026013-P01 from Novus Biologicals

Category Protein
Prices $305.00, $445.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

L3MBTL - H00026013-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

L3MBTL fusion protein - Ag5326 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

L3MBTL fusion protein - ag4860 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human L3MBTL, His-tagged - L3MBTL-488H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Lethal(3)malignant brain tumor-like protein 1(L3MBTL1) - CSB-YP897111HU CSB-EP897111HU CSB-BP897111HU CSB-MP897111HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

L3MBTL1 (transcript variant I) - TP308022 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
L3MBTL1

Recombinant Human L3MBTL1 Protein, GST-tagged - L3MBTL1-124H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human L3MBTL1 Protein, His-tagged - L3MBTL1-125H from Creative Biomart

Category Protein
Source E.coli
Species Human

L3MBTL1 antibody ( pAb ) , 200 ul - HM-AB1677 from Novatein Biosciences

Prices $442.00
Sizes 200 µl

L3MBTL1 antibody ( pAb ) , 10 ul - HM-AB1678 from Novatein Biosciences

Prices $91.00
Sizes 10 µl

L3MBTL1-Blocking-Peptide-Center - BP21815c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

L3MBTL1 Peptide, Human - M34GP08505H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

L3MBTL1 Recombinant Protein Antigen - NBP2-58171PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Lethal (3) malignant brain tumor-like protein 1 (L3MBTL1), Recombinant Protein - MBS1428047 from MyBioSource

Category Protein
Prices $1,565.00, $1,565.00, $1,795.00, $1,795.00, $2,700.00, $2,700.00, $3,140.00, $3,140.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Human L3MBTL1 protein, GST-tagged - L3MBTL1-254H from Creative Biomart

Category Protein
Source E. coli
Species Human

Recombinant Human CBX1 protein, GST-tagged - L3MBTL1-255H from Creative Biomart

Category Protein
Source E. coli
Species Human

Recombinant Human L3MBTL Protein, MYC/DDK-tagged - L3MBTL-172H from Creative Biomart

Category Protein
Source HEK293
Species Human
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