| Gene Symbol |
PAAF1
|
| Entrez Gene |
80227
|
| Alt Symbol |
PAAF, Rpn14, WDR71
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasomal ATPase-associated factor 1
|
| Other Description |
WD repeat domain 71|WD repeat-containing protein 71
|
| Swissprots |
Q7Z500 Q53HS9 B7ZAS9 Q8TBU6 Q4G165 B4DPB0 A6NDR5 Q9BRP4 Q9HAB6
|
| Accessions |
EAW74917 EAW74918 EAW74919 Q9BRP4 AF087895 AAP97194 AK021910 BAB13933 AK222501 BAD96221 AK225520 AK298258 BAG60522 AK309133 AK316394 BAH14765 BC006142 AAH06142 BC021541 AAH21541 BC028628 AAH28628 BC028677 BC045774 CD243380 DC354686 HQ448172 ADQ32653 XM_005274308 XP_005274365 XM_005274309 XP_005274366 XM_005274310 XP_005274367 XM_011545272 XP_011543574 XM_011545273 XP_011543575 XR_950069 NM_001267803 NP_001254732 NM_001267804 NP_001254733 NM_001267805 NP_001254734 NM_001267806 NP_001254735 NM_025155 NP_079431
|
| Function |
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. {ECO:0000269|PubMed:15831487, ECO:0000269|PubMed:17289585, ECO:0000269|PubMed:22316138}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in kidney, brain and testis. {ECO:0000269|PubMed:15831487}.
|