| Gene Symbol |
UBE3C
|
| Entrez Gene |
9690
|
| Alt Symbol |
HECTH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin protein ligase E3C
|
| Other Description |
ubiquitin-protein isopeptide ligase (E3)|ubiquitin-protein ligase E3C
|
| Swissprots |
Q9UDU3 Q15386 A6NCP3 Q8TC15 Q96CR4 A4D235
|
| Accessions |
AAD51453 EAL23922 EAX04567 EAX04568 EAX04569 Q15386 AA596042 AK127280 AK295138 BAG58161 BC014029 AAH14029 BC026241 AAH26241 CD366848 D13635 BAA02799 DB085748 DB454915 XM_005249564 XP_005249621 XM_011516714 XP_011515016 XR_927552 NM_014671 NP_055486
|
| Function |
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:9575161}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|